Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | FABP4 | P15090 | 2/20 | 0.47 |
| ▸ | FABP3 | P05413 | 1/20 | 0.47 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18991401 | 0.81 | L3MBTL1 (0.53) | POLBUSP2ALDH1A1KDM4EKMT2A | |
| SCHEMBL11557939 | 0.76 | TMEM97 (0.48) | CNR2LMNA | |
| SCHEMBL11556885 | 0.76 | TMEM97 (0.48) | CNR2LMNA | |
| SCHEMBL15971194 | 0.76 | CNR2 (0.41) | POLBUSP2ALDH1A1KDM4EKMT2A | |
| SCHEMBL11556504 | 0.75 | SMN1; SMN2 (0.48) | POLBUSP2ALDH1A1KDM4EKMT2A | |
| SCHEMBL11559529 | 0.75 | HIF1A (0.47) | POLBALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL18991537 | 0.75 | USP2 (1.00) | POLBUSP2KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL18838544 | 0.75 | ALDH1A1 (0.64) | POLBALDH1A1FABP4FABP3FABP5 | |
| SCHEMBL11558957 | 0.74 | HIF1A (0.46) | POLBALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL11557562 | 0.74 | SMN1; SMN2 (0.49) | POLBUSP2ALDH1A1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11752128-B2 | Benzimidazoles and indoles as taro inhibitors | MERCK SHARP & DOHME CORPORATION (US) | 2023-09-12 | — | — | US | disclosed |
| EP-3389785-B1 | BENZIMIDAZOLES AND INDOLES AS TARO INHIBITORS | MERCK SHARP & DOHME (US) | 2023-08-16 | — | — | EP | disclosed |
| US-20210346344-A1 | BENZIMIDAZOLES AND INDOLES AS TARO INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-11-11 | — | — | US | disclosed |
| US-11141403-B2 | Benzimidazoles and indoles as taro inhibitors | MERCK SHARP & DOHME CORP (US) | 2021-10-12 | — | — | US | disclosed |
| US-20200261410-A1 | BENZIMIDAZOLES AND INDOLES AS TARO INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-08-20 | — | — | US | disclosed |
| EP-3389785-A1 | BENZIMIDAZOLES AND INDOLES AS TARO INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2018-10-24 | — | — | EP | disclosed |
| WO-2017106134-A1 | BENZIMIDAZOLES AND INDOLES AS TARO INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2017-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11141403-B2 | Benzimidazoles and indoles as taro inhibitors | CSDE1, IDO1, TMBIM6 | POLB 343/4885USP2 4637/4885ALDH1A1 2028/4885 |
| US-20210346344-A1 | BENZIMIDAZOLES AND INDOLES AS TARO INHIBITORS | CSDE1, IDO1, TMBIM6 | POLB 343/4885USP2 4637/4885ALDH1A1 2028/4885 |
| US-11752128-B2 | Benzimidazoles and indoles as taro inhibitors | CSDE1, IDO1, TMBIM6 | POLB 343/4885USP2 4637/4885ALDH1A1 2028/4885 |
| US-20200261410-A1 | BENZIMIDAZOLES AND INDOLES AS TARO INHIBITORS | CSDE1, IDO1, TMBIM6 | POLB 343/4885USP2 4637/4885ALDH1A1 2028/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.