Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 6/20 | 0.65 |
| ▸ | F13A1 | P00488 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TGM1 | P22735 | 1/20 | 0.49 |
| ▸ | TGM3 | Q08188 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 6/20 | 0.48 |
| ▸ | JAK3 | P52333 | 2/20 | 0.48 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.47 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.47 |
| ▸ | ITK | Q08881 | 4/20 | 0.47 |
| ▸ | BTK | Q06187 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4103284 | 0.87 | TGM2 (0.76) | TGM2F13A1LMNATGM1TGM3 | |
| SCHEMBL1119155 | 0.80 | TGM2 (0.67) | TGM2F13A1LMNATGM1TGM3 | |
| SCHEMBL17397388 | 0.80 | TGM2 (0.67) | TGM2F13A1LMNATGM1TGM3 | |
| SCHEMBL29380510 | 0.80 | TGM2 (0.67) | TGM2F13A1LMNATGM1TGM3 | |
| SCHEMBL1380349 | 0.79 | TGM2 (0.65) | TGM2BTK | |
| SCHEMBL8472105 | 0.79 | TGM2 (0.65) | TGM2LMNAEGFRBTK | |
| SCHEMBL1381249 | 0.79 | TGM2 (1.00) | TGM2F13A1LMNATGM1TGM3 | |
| SCHEMBL22600367 | 0.79 | TGM2 (0.65) | TGM2F13A1LMNATGM1TGM3 | |
| SCHEMBL2318657 | 0.79 | TGM2 (0.65) | TGM2F13A1LMNATGM1TGM3 | |
| SCHEMBL6355891 | 0.79 | TGM2 (0.65) | TGM2EGFRLPAR1LPAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076620-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |
| US-9682931-B2 | Aryloyl(oxy or amino)pentafluorosulfanylbenzene compound, pharmaceutically acceptable salt thereof, and prodrugs thereof | UBE INDUSTRIES, LTD. (JP) | 2017-06-20 | — | — | US | disclosed |