Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | AQP1 | P29972 | 1/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.34 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.34 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21018920 | 0.91 | LMNA (0.49) | LMNAKDM4EUSP2ALDH1A1CA2 | |
| SCHEMBL2741957 | 0.90 | LMNA (0.52) | LMNAKDM4EUSP2ALDH1A1CA2 | |
| SCHEMBL10222972 | 0.86 | LMNA (0.44) | LMNAKDM4EUSP2ALDH1A1CA2 | |
| SCHEMBL2741959 | 0.84 | ALDH1A1 (0.54) | LMNAKDM4EUSP2ALDH1A1CA2 | |
| SCHEMBL18993691 | 0.84 | LMNA (0.46) | LMNAKDM4EUSP2ALDH1A1CA2 | |
| SCHEMBL18993748 | 0.84 | ALDH1A1 (0.46) | LMNAKDM4EUSP2ALDH1A1CA2 | |
| SCHEMBL18993679 | 0.83 | ALDH1A1 (0.46) | LMNAKDM4EUSP2ALDH1A1CA2 | |
| SCHEMBL2741953 | 0.81 | LMNA (0.50) | LMNAKDM4EUSP2ALDH1A1CA2 | |
| SCHEMBL2877269 | 0.80 | LMNA (0.49) | LMNAKDM4EUSP2ALDH1A1CA2 | |
| SCHEMBL2741952 | 0.80 | LMNA (0.49) | LMNAKDM4EUSP2ALDH1A1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9682928-B2 | Bumetanide analogs, compositions and methods of use | NEUROPRO THERAPEUTICS, INC. (US) | 2017-06-20 | — | — | US | disclosed |