Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | BLM | P54132 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | AQP1 | P29972 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21018922 | 0.92 | LMNA (0.50) | ALDH1A1BLMLMNAKDM4EUSP2 | |
| SCHEMBL2741957 | 0.90 | LMNA (0.52) | ALDH1A1BLMLMNAKDM4EUSP2 | |
| SCHEMBL18993636 | 0.86 | ALDH1A1 (0.60) | ALDH1A1BLMLMNAKDM4EUSP2 | |
| SCHEMBL2741959 | 0.84 | ALDH1A1 (0.54) | ALDH1A1BLMLMNAKDM4EUSP2 | |
| SCHEMBL18993689 | 0.84 | LMNA (0.46) | ALDH1A1BLMLMNAKDM4EUSP2 | |
| SCHEMBL18993691 | 0.84 | LMNA (0.46) | ALDH1A1BLMLMNAKDM4EUSP2 | |
| SCHEMBL18993679 | 0.83 | ALDH1A1 (0.46) | ALDH1A1BLMLMNAKDM4EUSP2 | |
| SCHEMBL2741953 | 0.81 | LMNA (0.50) | ALDH1A1BLMLMNAKDM4EUSP2 | |
| SCHEMBL2877269 | 0.80 | LMNA (0.49) | ALDH1A1BLMLMNAKDM4EUSP2 | |
| SCHEMBL2741952 | 0.80 | LMNA (0.49) | ALDH1A1BLMLMNAKDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9682928-B2 | Bumetanide analogs, compositions and methods of use | NEUROPRO THERAPEUTICS, INC. (US) | 2017-06-20 | — | — | US | disclosed |