Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18647998 | 0.84 | HPGD (0.50) | HPGDTDP1PARP1TAS1R3TAS1R1 | |
| SCHEMBL12948133 | 0.81 | GAA (0.41) | TAS1R3TAS1R1SMN1; SMN2ALDH1A1CYP2C19 | |
| SCHEMBL26064182 | 0.78 | HPGD (0.47) | HPGDTDP1PARP1TAS1R3TAS1R1 | |
| SCHEMBL24198753 | 0.78 | HCAR2 (0.50) | CYP2C19POLB | |
| SCHEMBL855152 | 0.76 | PARP1 (0.59) | HPGDTDP1PARP1HDAC8HDAC6 | |
| SCHEMBL29429340 | 0.74 | PARP1 (0.57) | HPGDTDP1PARP1HDAC8HDAC6 | |
| SCHEMBL11065475 | 0.74 | PARP1 (0.57) | HPGDTDP1PARP1HDAC8HDAC6 | |
| SCHEMBL12508632 | 0.73 | ACHE (0.41) | SMN1; SMN2POLB | |
| SCHEMBL22420533 | 0.73 | CYP2C9 (0.49) | HPGDSMN1; SMN2KMT2APOLB | |
| SCHEMBL21919758 | 0.73 | CA5A (0.36) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9682936-B2 | Morphan and morphinan analogues, and methods of use | ALKERMES PHARMA IRELAND LIMITED (IE) | 2017-06-20 | — | — | US | disclosed |