Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 2/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 12/20 | 0.43 |
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | ITK | Q08881 | 1/20 | 0.39 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18994995 | 0.83 | CHEK1 (0.49) | ULK1JAK2CDK1ULK2KDR | |
| SCHEMBL18995069 | 0.80 | ULK1 (0.44) | ULK1JAK2CDK1ULK2KDR | |
| SCHEMBL15337703 | 0.79 | ULK1 (0.41) | ULK1EGFRLRRK2ITKULK2 | |
| SCHEMBL15337510 | 0.79 | ULK1 (0.41) | ULK1EGFRLRRK2ITKULK2 | |
| SCHEMBL17694845 | 0.76 | TBK1 (0.34) | TBK1JAK2EGFRATR | |
| SCHEMBL15321629 | 0.76 | SYK (0.47) | ATR | |
| SCHEMBL19836242 | 0.74 | TBK1 (0.41) | ULK1TBK1LRRK2CDK1ULK2 | |
| SCHEMBL19836220 | 0.74 | TBK1 (0.41) | ULK1TBK1LRRK2CDK1ULK2 | |
| SCHEMBL19836407 | 0.73 | ULK1 (0.40) | ULK1CDK1ULK2KDR | |
| SCHEMBL15790797 | 0.72 | SYK (0.51) | ULK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9682976-B2 | Protein kinase C inhibitors and uses thereof | RIGEL PHARMACEUTICALS, INC. (US) | 2017-06-20 | — | — | US | disclosed |