Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 8/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | ULK2 | Q8IYT8 | 2/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.39 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.39 |
| ▸ | STK17B | O94768 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 3/20 | 0.38 |
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18995012 | 0.88 | BCL6 (0.43) | STK17ASTK17BSYK | |
| SCHEMBL19527725 | 0.86 | TNIK (0.39) | AURKAKDRAURKBSTK17ACDK1 | |
| SCHEMBL18994995 | 0.85 | CHEK1 (0.49) | ULK1AURKAKDRAURKBULK2 | |
| SCHEMBL19527748 | 0.84 | TBK1 (0.37) | ULK1FLT3SYK | |
| SCHEMBL18995121 | 0.83 | NPC1 (0.47) | JAK2 | |
| SCHEMBL19836407 | 0.81 | ULK1 (0.40) | ULK1AURKAKDRAURKBULK2 | |
| SCHEMBL18994999 | 0.80 | ULK1 (0.43) | ULK1KDRULK2CDK1JAK2 | |
| SCHEMBL19836220 | 0.78 | TBK1 (0.41) | ULK1AURKAKDRAURKBULK2 | |
| SCHEMBL19836242 | 0.78 | TBK1 (0.41) | ULK1AURKAKDRAURKBULK2 | |
| SCHEMBL15337596 | 0.74 | ULK1 (0.43) | ULK1ULK2PTK2KITFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2833889-B1 | PROTEIN KINASE C INHIBITORS AND USES THEREOF | RIGEL PHARMACEUTICALS INC (US) | 2017-11-01 | — | — | EP | disclosed |
| US-9682976-B2 | Protein kinase C inhibitors and uses thereof | RIGEL PHARMACEUTICALS, INC. (US) | 2017-06-20 | — | — | US | disclosed |