Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 19/20 | 0.55 |
| ▸ | JAK2 | O60674 | 9/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19527758 | 0.83 | NPC1 (0.46) | TBK1JAK2 | |
| SCHEMBL18994991 | 0.83 | NPC1 (0.47) | TBK1JAK2 | |
| SCHEMBL19836466 | 0.82 | CDK4 (0.51) | TBK1JAK2 | |
| SCHEMBL18995151 | 0.80 | BRD4 (0.48) | TBK1JAK2 | |
| SCHEMBL17631785 | 0.80 | TBK1 (0.64) | TBK1JAK2 | |
| SCHEMBL18995035 | 0.80 | CSF1R (0.40) | TBK1JAK2 | |
| SCHEMBL15337260 | 0.77 | TBK1 (0.46) | TBK1JAK2 | |
| SCHEMBL19527807 | 0.77 | TBK1 (0.46) | TBK1JAK2 | |
| SCHEMBL17631378 | 0.76 | TBK1 (0.77) | TBK1JAK2 | |
| SCHEMBL2551874 | 0.75 | CSF1R (0.56) | JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9682976-B2 | Protein kinase C inhibitors and uses thereof | RIGEL PHARMACEUTICALS, INC. (US) | 2017-06-20 | — | — | US | disclosed |