Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 3/20 | 0.46 |
| ▸ | CSF1R | P07333 | 3/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.46 |
| ▸ | WEE1 | P30291 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.41 |
| ▸ | SYK | P43405 | 3/20 | 0.41 |
| ▸ | CDK1 | P06493 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19836466 | 0.83 | CDK4 (0.51) | NPC1RAB9ACDK4CSF1RCDK6 | |
| SCHEMBL18995043 | 0.83 | TBK1 (0.55) | JAK2TBK1 | |
| SCHEMBL19527758 | 0.82 | NPC1 (0.46) | NPC1RAB9ACDK4CSF1RCDK6 | |
| SCHEMBL18995151 | 0.82 | BRD4 (0.48) | NPC1RAB9ACDK4CSF1RCDK6 | |
| SCHEMBL18995121 | 0.77 | NPC1 (0.47) | NPC1RAB9AJAK2TBK1GRM5 | |
| SCHEMBL15336725 | 0.76 | EGFR (0.42) | CDK4CSF1RCDK6JAK2TBK1 | |
| SCHEMBL22860486 | 0.74 | CDK4 (0.63) | CDK4CSF1RCDK6CDK1CDK2 | |
| SCHEMBL29507838 | 0.74 | CDK4 (0.63) | CDK4CSF1RCDK6CDK1CDK2 | |
| SCHEMBL2551874 | 0.73 | CSF1R (0.56) | NPC1RAB9ACDK4CSF1RCDK6 | |
| SCHEMBL3955783 | 0.72 | AXL (0.59) | CSF1RJAK2TBK1LRRK2PAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9682976-B2 | Protein kinase C inhibitors and uses thereof | RIGEL PHARMACEUTICALS, INC. (US) | 2017-06-20 | — | — | US | disclosed |