⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30249644 | 0.80 | — | — | |
| SCHEMBL31521243 | 0.79 | SLC6A1 (0.32) | — | |
| SCHEMBL29080159 | 0.75 | PNMT (0.31) | — | |
| SCHEMBL11921322 | 0.75 | SLC6A1 (0.30) | — | |
| SCHEMBL24050612 | 0.70 | KMT2A (0.39) | — | |
| SCHEMBL5230146 | 0.70 | PLG (0.33) | — | |
| SCHEMBL30790418 | 0.69 | — | — | |
| SCHEMBL30790567 | 0.69 | — | — | |
| SCHEMBL25337578 | 0.67 | — | — | |
| SCHEMBL24510486 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE42412-E1 | Materials and methods for the treatment of gastroesophageal reflux disease | ARYX THERAPEUTICS, INC. (US) | 2011-05-31 | — | — | US | disclosed |
| US-20030216387-A1 | Materials and methods for the treatment of gastroesophageal reflux disease | ARYX THERAPEUTICS | 2003-11-20 | — | — | US | disclosed |
| US-6552046-B2 | Cisapride | ARYX THERAPEUTICS | 2003-04-22 | — | — | US | disclosed |
| EP-1296684-A2 | TREATMENT OF GASTROESOPHAGEAL REFLUX DISEASE USING PIPERIDINE DERIVATIVES | ARYx Therapeutics (US) | 2003-04-02 | — | — | EP | disclosed |
| US-20020025970-A1 | Materials and methods for the treatment of gastroesophageal reflux disease | ARYX THERAPEUTICS, INC. | 2002-02-28 | — | — | US | disclosed |
| WO-2001093849-A2 | TREATMENT OF GASTROESOPHAGEAL REFLUX DISEASE USING PIPERIDINE DERIVATIVES | ARYX THERAPEUTICS (US) | 2001-12-13 | — | — | WO | disclosed |
| US-5665884-A | Preparation of cisapride | TORCAN CHEMICAL LTD. (CA) | 1997-09-09 | — | — | US | disclosed |
| US-5585387-A | Prepration of cisapride | TORCAN CHEMICAL LTD. (CA) | 1996-12-17 | — | — | US | disclosed |
| WO-1996011186-A1 | PREPARATION OF CISAPRIDE | TORCAN CHEMICAL LTD. (CA) | 1996-04-18 | — | — | WO | disclosed |
| US-5137896-A | Useful in treatment of gastrointestinal and psychic disorder; analgesic, antiemetic and antiulcer agent | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-08-11 | — | — | US | disclosed |
| US-5057525-A | Stimulators of gastrointestinal motility | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-10-15 | — | — | US | disclosed |
| US-4962115-A | Stimulate motility of gastrointestinal system | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-10-09 | — | — | US | disclosed |
| EP-0076530-B1 | NOVEL N-(3-HYDROXY-4-PIPERIDINYL)BENZAMIDE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-12-11 | — | — | EP | disclosed |
| EP-0076530-A2 | Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1983-04-13 | — | — | EP | disclosed |