Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MME | P08473 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.35 |
| ▸ | NAALAD2 | Q9Y3Q0 | 2/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1899687 | 1.00 | POLB (0.39) | POLBEPHX1SMN1; SMN2MMEKDM4E | |
| SCHEMBL29025098 | 1.00 | POLB (0.39) | POLBEPHX1SMN1; SMN2MMEKDM4E | |
| SCHEMBL30471284 | 0.82 | EPHX1 (0.36) | POLBEPHX1SMN1; SMN2CA2ALDH1A1 | |
| SCHEMBL1236443 | 0.81 | NOD1 (0.49) | EPHX1MMEMAPTCA2FOLH1 | |
| SCHEMBL8178933 | 0.81 | NOD1 (0.49) | EPHX1MMEMAPTCA2FOLH1 | |
| SCHEMBL7133053 | 0.81 | TGFBR1 (0.50) | POLBSMN1; SMN2MMECA2ALDH1A1 | |
| SCHEMBL19083738 | 0.81 | POLB (0.40) | POLBSMN1; SMN2MMEKDM4EMAPT | |
| SCHEMBL7133055 | 0.81 | TGFBR1 (0.50) | POLBSMN1; SMN2MMECA2ALDH1A1 | |
| SCHEMBL1349241 | 0.81 | POLB (0.40) | POLBSMN1; SMN2MMEKDM4EMAPT | |
| SCHEMBL31406277 | 0.81 | POLB (0.40) | POLBSMN1; SMN2MMEKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513054-B1 | BICYCLIC DERIVATIVES USEFUL AS INHIBITORS OF DPP-1 | JANSSEN PHARMACEUTICA NV (BE) | 2016-03-09 | — | — | EP | disclosed |
| CN-102596321-B | Alkynyl derivatives useful as dpp-1 inhibitors | JANSSEN PHARMACEUTICA NV | 2014-11-19 | — | — | CN | disclosed |
| CN-102753524-B | Bicyclic derivatives useful as inhibitors of dpp-1 | ANSSEN PHARMACEUTICA NV | 2014-11-05 | — | — | CN | disclosed |
| EP-2493571-B1 | ALKYNYL DERIVATIVES USEFUL AS DPP-1 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-07-23 | — | — | EP | disclosed |
| US-8633322-B2 | Alkynyl derivatives useful as DPP-1 inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-21 | — | — | US | disclosed |
| US-8552032-B2 | Bicyclic derivatives useful as inhibitors of DPP-1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-10-08 | — | — | US | disclosed |
| EP-2513054-A1 | BICYCLIC DERIVATIVES USEFUL AS INHIBITORS OF DPP-1 | Janssen Pharmaceutica, N.V. (BE) | 2012-10-24 | — | — | EP | disclosed |
| EP-2493571-A1 | ALKYNYL DERIVATIVES USEFUL AS DPP-1 INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2012-09-05 | — | — | EP | disclosed |
| US-20110152321-A1 | BICYCLIC DERIVATIVES USEFUL AS INHIBITORS OF DPP-1 | JANSSEN PHARMACEUTICA (BE) | 2011-06-23 | — | — | US | disclosed |
| WO-2011075634-A1 | BICYCLIC DERIVATIVES USEFUL AS INHIBITORS OF DPP-1 | JANSSEN PHARMACEUTICA NV (BE) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011059731-A1 | ALKYNYL DERIVATIVES USEFUL AS DPP-1 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-19 | — | — | WO | disclosed |
| US-20110105562-A1 | ALKYNYL DERIVATIVES USEFUL AS DPP-1 INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-05-05 | — | — | US | disclosed |
| EP-1558238-A4 | BETA-HYDROXYPHENYLALDYLAMINES AND THEIR USE FOR TREATING GLAUCOMA | UNIV VIRGINIA COMMONWEALTH (US) | 2006-08-30 | — | — | EP | disclosed |
| US-20060106106-A1 | Beta-hydroxyphenylalkylamines and their use for treating glaucoma | VIRGINIA COMMONWEALTH UNIVERSITY | 2006-05-18 | — | — | US | disclosed |
| EP-1558238-A2 | BETA-HYDROXYPHENYLALDYLAMINES AND THEIR USE FOR TREATING GLAUCOMA | Virginia Commonwealth University (US) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004028451-A2 | β-HYDROXYPHENYLALKYLAMINES AND THEIR USE FOR TREATING GLAUCOMA | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2004-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152321-A1 | BICYCLIC DERIVATIVES USEFUL AS INHIBITORS OF DPP-1 | DPP4, DPP7, DPP3 | POLB 3693/4885EPHX1 2466/4885SMN1; SMN2 2506/4885 |
| US-20110105562-A1 | ALKYNYL DERIVATIVES USEFUL AS DPP-1 INHIBITORS | DPP4, DPP3, DPP7 | POLB 4251/4885EPHX1 2179/4885SMN1; SMN2 2443/4885 |
| US-20060106106-A1 | Beta-hydroxyphenylalkylamines and their use for treating glaucoma | PDE3A, QDPR, PDE2A | POLB 1050/4885EPHX1 1045/4885SMN1; SMN2 4673/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.