Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB1 | P20618 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.43 |
| ▸ | FURIN | P09958 | 1/20 | 0.42 |
| ▸ | MASP2 | O00187 | 3/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | CPA1 | P15085 | 1/20 | 0.38 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.38 |
| ▸ | HTRA1 | Q92743 | 4/20 | 0.38 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.37 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.37 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1906175 | 1.00 | PSMB1 (0.43) | PSMB1PSMB5PSMB2KLKB1FURIN | |
| SCHEMBL1902458 | 1.00 | PSMB1 (0.43) | PSMB1PSMB5PSMB2KLKB1FURIN | |
| SCHEMBL1906161 | 0.89 | NAMPT (0.46) | KLKB1FURINMASP2NAMPTCPB2 | |
| SCHEMBL1904034 | 0.89 | NAMPT (0.46) | KLKB1FURINMASP2NAMPTCPB2 | |
| SCHEMBL1904039 | 0.89 | NAMPT (0.46) | KLKB1FURINMASP2NAMPTCPB2 | |
| SCHEMBL1903937 | 0.89 | PSMB1 (0.48) | PSMB1PSMB5PSMB2KLKB1FURIN | |
| SCHEMBL1906377 | 0.89 | PSMB1 (0.48) | PSMB1PSMB5PSMB2KLKB1FURIN | |
| SCHEMBL1431871 | 0.88 | MASP2 (0.44) | PSMB1PSMB5PSMB2KLKB1FURIN | |
| SCHEMBL3147989 | 0.88 | MASP2 (0.44) | PSMB1PSMB5PSMB2KLKB1FURIN | |
| SCHEMBL3148014 | 0.88 | MASP2 (0.44) | PSMB1PSMB5PSMB2KLKB1FURIN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | claimed |
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | disclosed |