Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 3/20 | 0.45 |
| ▸ | TDO2 | P48775 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 2/20 | 0.44 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | PDE9A | O76083 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28901729 | 0.86 | POLB (0.70) | POLBKDM4EALDH1A1HPGDGAA | |
| SCHEMBL19002277 | 0.82 | ACMSD (0.44) | POLBKDM4EALDH1A1GAAACMSD | |
| SCHEMBL11023464 | 0.70 | KDM4E (0.46) | KDM4EALDH1A1HPGDGAAPIM1 | |
| SCHEMBL20340038 | 0.70 | KDM4E (0.56) | KDM4EALDH1A1HPGDGAAPIM1 | |
| SCHEMBL5937494 | 0.69 | ACMSD (0.61) | POLBKDM4EALDH1A1HPGDGAA | |
| SCHEMBL28843348 | 0.69 | ACMSD (0.67) | POLBKDM4EGAAACMSDPIM1 | |
| SCHEMBL28477518 | 0.69 | ACMSD (0.64) | POLBKDM4EALDH1A1HPGDGAA | |
| SCHEMBL30051338 | 0.69 | ACMSD (0.64) | POLBKDM4EALDH1A1HPGDGAA | |
| SCHEMBL30049841 | 0.69 | MAPK14 (0.50) | KDM4EALDH1A1HPGDGAAIDO1 | |
| SCHEMBL13946114 | 0.69 | MAPK14 (0.50) | KDM4EALDH1A1HPGDGAAIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017106552-A1 | POTENTIATORS OF BETA-LACTAM ANTIBIOTICS AND COMBINATION THERAPY | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2017-06-22 | — | — | WO | disclosed |