Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | UBE2M | P61081 | 6/20 | 0.47 |
| ▸ | DCUN1D1 | Q96GG9 | 6/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18997284 | 0.87 | RIPK1 (0.51) | HTTCYP2C19THRBPDE4BUBE2M | |
| SCHEMBL24827533 | 0.85 | HTT (0.52) | HTTCYP2C19PDE4BUBE2MDCUN1D1 | |
| SCHEMBL19049514 | 0.82 | RIPK1 (0.53) | HTTCYP2C19THRBPDE4BUBE2M | |
| SCHEMBL21901038 | 0.81 | TSHR (0.51) | HTTCYP2C19THRBPDE4BUBE2M | |
| SCHEMBL16373549 | 0.81 | PDE4B (0.52) | HTTCYP2C19THRBPDE4BUBE2M | |
| SCHEMBL17788534 | 0.78 | PDE4B (0.49) | HTTCYP2C19THRBPDE4BUBE2M | |
| SCHEMBL21393181 | 0.78 | MAPK1 (0.66) | ALOX5ALDH1A1MAPK1TSHRKMT2A | |
| SCHEMBL4463285 | 0.76 | ALOX5 (0.56) | ALOX5ALDH1A1MAPK1TSHRKMT2A | |
| SCHEMBL11967793 | 0.75 | RIPK1 (0.62) | ALOX5ALDH1A1MAPK1TSHRKMT2A | |
| SCHEMBL17983768 | 0.74 | ALOX5 (0.47) | CYP2C19ALOX5ALDH1A1MAPK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170174699-A1 | COMPOUNDS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASE | SHY Therapeutics LLC | 2017-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170174699-A1 | COMPOUNDS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASE | MAPK6, MAP3K6, MAPK4 | HTT 4394/4885CYP2C19 4701/4885THRB 1733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.