Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | MELK | Q14680 | 1/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL182186 | 0.81 | STIM1 (0.52) | MAP4K4MAPKAPK2MEN1NPC1RAB9A | |
| SCHEMBL182209 | 0.81 | ALDH1A1 (0.51) | MAP4K4MAPKAPK2MEN1NPC1RAB9A | |
| SCHEMBL2712427 | 0.76 | MAP4K4 (0.46) | MAP4K4MAPKAPK2MEN1NPC1RAB9A | |
| SCHEMBL6134377 | 0.76 | ALKBH2 (0.66) | MAP4K4MAPKAPK2MEN1NPC1RAB9A | |
| SCHEMBL182112 | 0.75 | MAP4K4 (0.56) | MAP4K4MAPKAPK2MEN1NPC1RAB9A | |
| SCHEMBL182549 | 0.75 | MAP4K4 (0.50) | MAP4K4MAPKAPK2MEN1NPC1RAB9A | |
| SCHEMBL182369 | 0.74 | HPGDS (0.63) | MAP4K4MAPKAPK2MEN1NPC1RAB9A | |
| SCHEMBL182343 | 0.74 | ALDH1A1 (0.51) | MAP4K4MAPKAPK2MEN1NPC1RAB9A | |
| SCHEMBL182124 | 0.73 | MAP4K4 (0.57) | MAP4K4MAPKAPK2MEN1NPC1RAB9A | |
| SCHEMBL182033 | 0.73 | MAP4K4 (0.77) | MAP4K4MAPKAPK2MEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2316452-A1 | Pyrrol derivatives, uses thereof | PTC Therapeutics, Inc. (US) | 2011-05-04 | — | — | EP | disclosed |