Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 2/20 | 0.33 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.33 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.33 |
| ▸ | SOD3 | P08294 | 2/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | NAAA | Q02083 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25653283 | 0.95 | GNAI3 (0.37) | GNAI3GNAO1GNAI1SOD3FAAH | |
| SCHEMBL25131961 | 0.95 | GNAI3 (0.37) | GNAI3GNAO1GNAI1SOD3FAAH | |
| SCHEMBL30531533 | 0.82 | SMN1; SMN2 (0.36) | GNAI3GNAO1GNAI1SOD3FAAH | |
| SCHEMBL1583383 | 0.79 | LMNA (0.35) | — | |
| SCHEMBL11364988 | 0.76 | LMNA (0.45) | FAAH | |
| SCHEMBL23921699 | 0.74 | FAAH (0.51) | GNAI3GNAO1GNAI1FAAHNAAA | |
| SCHEMBL25132003 | 0.74 | FAAH (0.51) | GNAI3GNAO1GNAI1FAAHNAAA | |
| SCHEMBL23030500 | 0.72 | LMNA (0.47) | — | |
| SCHEMBL6535777 | 0.72 | LMNA (0.47) | FAAH | |
| SCHEMBL19897475 | 0.72 | LMNA (0.47) | FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2938344-B1 | PIPERAZINE-SUBSTITUTED [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES | MERCK SHARP & DOHME (US) | 2017-06-21 | — | — | EP | disclosed |