Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13119906 | 1.00 | SIGMAR1 (0.30) | SIGMAR1 | |
| SCHEMBL19122485 | 1.00 | SIGMAR1 (0.30) | SIGMAR1 | |
| SCHEMBL9284499 | 0.97 | FDPS (0.32) | — | |
| SCHEMBL13119908 | 0.94 | SIGMAR1 (0.33) | SIGMAR1 | |
| SCHEMBL26854563 | 0.94 | SIGMAR1 (0.33) | SIGMAR1 | |
| SCHEMBL26854562 | 0.94 | SIGMAR1 (0.33) | SIGMAR1 | |
| SCHEMBL26253292 | 0.80 | HRH3 (0.38) | SIGMAR1 | |
| SCHEMBL23108395 | 0.78 | MC4R (0.39) | — | |
| SCHEMBL25650083 | 0.78 | — | — | |
| SCHEMBL14169485 | 0.76 | OPRD1 (0.35) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170174675-A9 | Modulators of Cystic Fibrosis Transmembrane Conductance Regulator | VERTEX PHARMACEUTICALS INCORPORATED | 2017-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170174675-A9 | Modulators of Cystic Fibrosis Transmembrane Conductance Regulator | CFTR, SCNN1G, SCNN1B | SIGMAR1 1635/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.