Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.80 |
| ▸ | MEN1 | O00255 | 3/20 | 0.80 |
| ▸ | POLB | P06746 | 2/20 | 0.80 |
| ▸ | PTPN1 | P18031 | 12/20 | 0.77 |
| ▸ | MAPT | P10636 | 2/20 | 0.77 |
| ▸ | PKM | P14618 | 2/20 | 0.77 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.77 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.77 |
| ▸ | GALK1 | P51570 | 1/20 | 0.77 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.71 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.71 |
| ▸ | CDC25B | P30305 | 1/20 | 0.71 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.71 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.71 |
| ▸ | PTGES | O14684 | 2/20 | 0.70 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.69 |
| ▸ | BLM | P54132 | 2/20 | 0.68 |
| ▸ | DNMT1 | P26358 | 2/20 | 0.68 |
| ▸ | PLEC | Q15149 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1900374 | 1.00 | KMT2A (0.80) | KMT2AMEN1POLBPTPN1MAPT | |
| SCHEMBL1900377 | 1.00 | KMT2A (0.80) | KMT2AMEN1POLBPTPN1MAPT | |
| SCHEMBL1904142 | 0.90 | PTPN1 (0.93) | KMT2AMEN1POLBPTPN1MAPT | |
| SCHEMBL3178417 | 0.90 | PTPN1 (0.93) | KMT2AMEN1POLBPTPN1MAPT | |
| SCHEMBL1904141 | 0.90 | PTPN1 (0.93) | KMT2AMEN1POLBPTPN1MAPT | |
| SCHEMBL1905824 | 0.90 | KMT2A (0.80) | KMT2AMEN1POLBPTPN1MAPT | |
| SCHEMBL3186009 | 0.90 | KMT2A (0.80) | KMT2AMEN1POLBPTPN1MAPT | |
| SCHEMBL1905826 | 0.90 | KMT2A (0.80) | KMT2AMEN1POLBPTPN1MAPT | |
| SCHEMBL1904875 | 0.89 | KMT2A (1.00) | KMT2AMEN1POLBPTPN1MAPT | |
| SCHEMBL1904877 | 0.89 | KMT2A (1.00) | KMT2AMEN1POLBPTPN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947717-B2 | Inhibitors of lethal factor protease | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2011-05-24 | — | — | US | disclosed |
| US-20100016292-A1 | INHIBITORS OF LETHAL FACTOR PROTEASE | THE BURNHAM INSTITUTE (US) | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016292-A1 | INHIBITORS OF LETHAL FACTOR PROTEASE | APAF1, F11, SERPINB1 | KMT2A 3345/4885MEN1 1839/4885POLB 3712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.