SCHEMBL1900599

SCHEMBL1900599

COc1c(C(C)(C)C)cc(C)cc1[Si](C)(C)Cl

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
CA2 P00918 2/20 0.38
POLB P06746 1/20 0.38
TYR P14679 1/20 0.38
TSHR P16473 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
CYP3A4 P08684 2/20 0.35
CYP2D6 P10635 1/20 0.35
ACHE P22303 1/20 0.35
PTGS2 P35354 3/20 0.34
PTGS1 P23219 1/20 0.34
ADRA2A P08913 1/20 0.34
ADRA2C P18825 1/20 0.34
ADRA1D P25100 1/20 0.34
ADRA1A P35348 1/20 0.34
ADRA1B P35368 1/20 0.34
HSPA5 P11021 1/20 0.33
DHFR P00374 1/20 0.32
CYP2C9 P11712 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5087083 0.85 SMN1; SMN2 (0.37) ALDH1A1SMN1; SMN2CA2POLBTYR
SCHEMBL5083900 0.83 CA1 (0.47) ALDH1A1CA2TSHRTDP1CYP3A4
SCHEMBL5090052 0.83 RARG (0.36) ALDH1A1CA2TSHRTDP1CYP3A4
SCHEMBL5085671 0.83 PTGS2 (0.34) ALDH1A1CA2TSHRTDP1CYP3A4
SCHEMBL4412722 0.82 ALDH1A1 (0.35) ALDH1A1SMN1; SMN2CA2POLBTYR
SCHEMBL5083764 0.79 ACHE (0.39) ACHE
SCHEMBL5857102 0.79 ALDH1A1 (0.52) ALDH1A1SMN1; SMN2CA2POLBTYR
SCHEMBL5090856 0.78 ACHE (0.40) ACHE
SCHEMBL5086490 0.78 ACHE (0.40) ACHE
SCHEMBL2914677 0.77 CYP3A4 (0.36) ALDH1A1SMN1; SMN2CA2POLBTYR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1582525-B1 Boron compound in the form of fine particles, component of catalyst for olefin polymerization comprising the same and method for producing the same SUMITOMO CHEMICAL CO (JP) 2014-12-17 EP disclosed
EP-2324918-A2 Boron compound in the form of fine particles, component of catalyst for olefin polymerization comprising the same and method for producing the same Sumitomo Chemical Company, Limited (JP) 2011-05-25 EP disclosed
US-7851569-B2 Rare earth metal complex, polymerization catalyst, and process for producing polymer SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-12-14 US disclosed
US-20090253875-A1 RARE EARTH METAL COMPLEX, POLYMERIZATION CATALYST AND METHOD FOR PRODUCING POLYMER SUMITOMO CHEMICAL COMPANY, LIMITED 2009-10-08 US disclosed
EP-1498178-B1 Transition metal complex and process for producing the same SUMITOMO CHEMICAL CO (JP) 2008-06-11 EP disclosed
US-20070197731-A1 Process for producing thermoplastic resin composition SUMITOMO CHEMICAL COMPANY, LIMITED 2007-08-23 US disclosed
EP-0887355-B1 PROCESS FOR PREPARING OLEFIN POLYMERS SUMITOMO CHEMICAL CO (JP) 2006-09-06 EP disclosed
EP-1582525-A2 Boron compound in the form of fine particles, component of catalyst for olefin polymerization comprising the same and method for producing the same Sumitomo Chemical Company, Limited (JP) 2005-10-05 EP disclosed
EP-0889062-B1 METHOD FOR FEEDING BORON COMPOUNDS SUMITOMO CHEMICAL CO (JP) 2005-08-03 EP disclosed
US-6870017-B2 Transition metal compound, catalyst for addition polymerization, and process for producing addition polymer SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2005-03-22 US disclosed
US-6197990-B1 REACTING CYCLOPENTADIENE AND METAL HYDRIDE IN PRESENCE OF AMINE COMPOUND SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-03-06 US disclosed
US-6184319-B1 HOMOPOLYMERIZING OLEFIN OR COPOLYMERIZING OLEFINS UNDER PRESSURE WITH CATALYST SYSTME COMPRISING TRANSITION METAL COMPLEX, ORGANOALUMINUM COMPOUND OR ALUMINOXANE AND BORON COMPOUND SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-02-06 US disclosed
EP-1043358-A1 THERMOPLASTIC OLEFIN ELASTOMER COMPOSITION FOR POWDER MOLDING, POWDER FOR POWDER MOLDING, AND MOLDED OBJECT SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2000-10-11 EP disclosed
EP-1038918-A1 THERMOPLASTIC OLEFIN ELASTOMER COMPOSITION Sumitomo Chemical Company, Limited (JP) 2000-09-27 EP disclosed
US-6121401-A OBTAINABLE BY POLYMERIZING PROPYLENE, AN ALPHA-OLEFIN HAVING 4-20 CARBON ATOMS, AND ETHYLENE IN THE PRESENCE OF A CATALYST FOR OLEFIN POLYMERIZATON INCLUDING AT LEAST ONE TRANSITION METAL COMPLEX, ONE ALUMINUM COMPOUND, ONE BORON COMPOUND SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2000-09-19 US disclosed
EP-0963990-A1 PROCESS FOR PRODUCING CYCLOPENTADIENYL METAL SALTS AND PROCESS FOR PRODUCING CYCLOPENTADIENE DERIVATIVES BY UTILIZING THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1999-12-15 EP disclosed
CN-1205340-A Propylene coplymer SUMITOMO CHEMICAL CO (JP) 1999-01-20 CN disclosed
EP-0889062-A1 METHOD FOR FEEDING BORON COMPOUNDS, FINE PARTICLES OF BORON COMPOUNDS, CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS COMPRISING THEM, AND PROCESSES FOR THE PRODUCTION OF THE PARTICLES SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1999-01-07 EP disclosed
EP-0887355-A1 PROCESS FOR PREPARING OLEFIN POLYMERS SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1998-12-30 EP disclosed
EP-0842939-A1 TRANSITION METAL COMPLEX, PROCESS FOR THE PREPARATION THEREOF, POLYMERIZATION CATALYST FOR OLEFINS CONTAINING THE COMPLEX, AND PROCESS FOR PRODUCING OLEFIN POLYMERS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-05-20 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090253875-A1 RARE EARTH METAL COMPLEX, POLYMERIZATION CATALYST AND METHOD FOR PRODUCING POLYMER RPS27L, LAS1L, AGL ALDH1A1 4278/4885SMN1; SMN2 2353/4885CA2 992/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.