Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 2/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.45 |
| ▸ | APP | P05067 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18999256 | 0.84 | CYP4F2 (0.43) | CYP4F2CYP4A11APPCYP1A2ABCB11 | |
| SCHEMBL19006343 | 0.76 | ALDH1A1 (0.38) | CYP4F2CYP4A11APPCYP1A2ABCB11 | |
| SCHEMBL16985332 | 0.73 | CYP4F2 (0.45) | CYP4F2CYP4A11CYP1A2ABCB11CYP3A4 | |
| SCHEMBL17122468 | 0.72 | MAPK1 (0.39) | CYP1A2TSHRMAPK1ALDH1A1LMNA | |
| SCHEMBL17298865 | 0.71 | CYP4F2 (0.46) | CYP4F2CYP4A11CYP1A2ABCB11CYP3A4 | |
| SCHEMBL14149259 | 0.71 | CYP4F2 (0.43) | CYP4F2CYP4A11CYP1A2ABCB11CYP3A4 | |
| SCHEMBL16423620 | 0.71 | CYP4F2 (0.43) | CYP4F2CYP4A11APPCYP1A2ABCB11 | |
| SCHEMBL13412138 | 0.71 | CYP4F2 (0.43) | CYP4F2CYP4A11CYP1A2ABCB11CYP3A4 | |
| SCHEMBL29427420 | 0.71 | ABCB11 (0.44) | CYP4F2CYP4A11CYP1A2ABCB11CYP3A4 | |
| SCHEMBL4076690 | 0.71 | CYP4F2 (0.43) | CYP4F2CYP4A11CYP1A2ABCB11CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170174693-A1 | SOLUBLE GUANYLATE CYCLASE STIMULATORS | MERCK SHARP & DOHME LLC | 2017-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170174693-A1 | SOLUBLE GUANYLATE CYCLASE STIMULATORS | GUCY1A1, GUCY1A2, PDE2A | CYP4F2 1819/4885CYP4A11 515/4885APP 1709/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.