Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.45 |
| ▸ | BACE1 | P56817 | 4/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | CTSD | P07339 | 3/20 | 0.44 |
| ▸ | LTA4H | P09960 | 3/20 | 0.44 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | CARM1 | Q86X55 | 4/20 | 0.42 |
| ▸ | PRMT6 | Q96LA8 | 4/20 | 0.42 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18626550 | 0.86 | MEN1 (0.54) | DRD4ALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL15587408 | 0.84 | ACHE (0.63) | DRD4TEAD1BACE1ACHELTA4H | |
| SCHEMBL5022826 | 0.83 | ALDH1A1 (0.51) | BACE1ACHECTSDALDH1A1CARM1 | |
| SCHEMBL18626507 | 0.82 | OPRL1 (0.43) | DRD4TEAD1LTA4HCARM1PRMT6 | |
| SCHEMBL29238649 | 0.82 | DRD4 (0.61) | DRD4BACE1ACHELTA4HCARM1 | |
| SCHEMBL19008153 | 0.80 | ALDH1A1 (0.56) | BACE1ACHECTSDALDH1A1KDM4E | |
| SCHEMBL18626538 | 0.80 | ALDH1A1 (0.60) | BACE1ACHECTSDALDH1A1KDM4E | |
| SCHEMBL19633483 | 0.79 | PRMT5 (0.50) | ALDH1A1RORCKDM4ELMNAMAPT | |
| SCHEMBL19008147 | 0.78 | ALDH1A1 (0.47) | BACE1ACHECTSDLTA4HALDH1A1 | |
| SCHEMBL13573575 | 0.78 | LTA4H (0.52) | DRD4TEAD1BACE1ACHELTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9855269-B2 | Aminoquinazoline and pyridopyrimidine derivatives | GENENTECH, INC. (US) | 2018-01-02 | — | — | US | disclosed |
| US-20170173026-A1 | AMINOQUINAZOLINE AND PYRIDOPYRIMIDINE DERIVATIVES | GENENTECH, INC. (US) | 2017-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170173026-A1 | AMINOQUINAZOLINE AND PYRIDOPYRIMIDINE DERIVATIVES | FLT4, FLT1, KDR | DRD4 2093/4885TEAD1 648/4885BACE1 3929/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.