Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 4/20 | 0.35 |
| ▸ | AKT2 | P31751 | 4/20 | 0.35 |
| ▸ | FASN | P49327 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1904598 | 0.86 | CYP3A4 (0.34) | ALOX15MAPTSMN1; SMN2CYP3A4CNR1 | |
| SCHEMBL1901170 | 0.86 | IP6K1 (0.43) | RAB9AHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL1899736 | 0.81 | AKT1 (0.48) | HSD17B10ALDH1A1AKT1AKT2ALOX15 | |
| SCHEMBL1900240 | 0.80 | VNN1 (0.41) | RAB9AKDM4EALDH1A1HPGDFASN | |
| SCHEMBL1535009 | 0.77 | AKT1 (0.45) | AKT1AKT2PLA2G2APLA2G4A | |
| SCHEMBL4849593 | 0.76 | PARP15 (0.41) | RAB9ALMNA | |
| SCHEMBL1904895 | 0.76 | AKT1 (0.36) | HSD17B10KDM4EALDH1A1HPGDAKT1 | |
| SCHEMBL1905065 | 0.73 | AKT1 (0.48) | HSD17B10ALDH1A1AKT1AKT2ALOX15 | |
| SCHEMBL1534384 | 0.73 | AKT1 (0.40) | RAB9AHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL1900535 | 0.73 | VNN1 (0.39) | HSD17B10KDM4EALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496566-A1 | AKT / PKB INHIBITORS | Almac Discovery Limited (GB) | 2012-09-12 | — | — | EP | disclosed |
| WO-2011055115-A1 | AKT / PKB INHIBITORS | ALMAC DISCOVERY LIMITED (GB) | 2011-05-12 | — | — | WO | disclosed |