Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IP6K1 | Q92551 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 6/20 | 0.38 |
| ▸ | AKT2 | P31751 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.34 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.34 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1900928 | 0.86 | RAB9A (0.36) | RAB9AKDM4EALDH1A1LMNAHSD17B10 | |
| SCHEMBL1904736 | 0.85 | AKT1 (0.51) | IP6K1RAB9AAKT1AKT2 | |
| SCHEMBL14119098 | 0.82 | IP6K1 (0.43) | IP6K1RAB9AKDM4EALDH1A1LMNA | |
| SCHEMBL1900766 | 0.81 | IP6K1 (0.38) | IP6K1RAB9AKDM4EALDH1A1LMNA | |
| SCHEMBL1900768 | 0.79 | AKT1 (0.42) | IP6K1RAB9AKDM4EALDH1A1LMNA | |
| SCHEMBL1904895 | 0.77 | AKT1 (0.36) | IP6K1KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL1901016 | 0.77 | AKT1 (0.51) | IP6K1AKT1AKT2 | |
| SCHEMBL14118761 | 0.74 | IP6K1 (0.41) | IP6K1RAB9AALDH1A1TSHRAKT1 | |
| SCHEMBL12095371 | 0.74 | AKT1 (0.34) | RAB9AALDH1A1AKT1AKT2KMT2A | |
| SCHEMBL1534347 | 0.73 | AKT1 (0.48) | IP6K1AKT1AKT2PLA2G2APLA2G4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496566-A1 | AKT / PKB INHIBITORS | Almac Discovery Limited (GB) | 2012-09-12 | — | — | EP | disclosed |
| WO-2011055115-A1 | AKT / PKB INHIBITORS | ALMAC DISCOVERY LIMITED (GB) | 2011-05-12 | — | — | WO | disclosed |