Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.36 |
| ▸ | TMIGD3 | P0DMS9 | 2/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1898044 | 0.87 | TLR8 (0.42) | ADORA2AADORA1ADORA3TLR8TLR7 | |
| SCHEMBL1901663 | 0.84 | TLR8 (0.44) | ADORA2AADORA1ADORA3TLR8TLR7 | |
| SCHEMBL1900995 | 0.83 | HSP90AB1 (0.43) | ADORA2AADORA1ADORA3TLR8TLR7 | |
| SCHEMBL1898389 | 0.80 | TLR7 (0.52) | ADORA2AADORA1ADORA3TLR8TLR7 | |
| SCHEMBL1896699 | 0.78 | CASR (0.37) | ADORA2AADORA1ADORA3TLR8TLR7 | |
| SCHEMBL1897133 | 0.75 | SLC6A4 (0.43) | TLR7 | |
| Hydrochloric Acid SCHEMBL1897933 | 0.74 | SLC6A4 (0.45) | TLR8TLR7 | |
| SCHEMBL1898043 | 0.72 | ELANE (0.43) | TLR8TLR7 | |
| SCHEMBL1894485 | 0.72 | TGFBR1 (0.39) | KCNH2 | |
| SCHEMBL12667267 | 0.71 | TLR7 (0.48) | TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943610-B2 | Pyrazolopyridine-1,4-diamines and analogs thereof | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2011-05-17 | — | — | US | disclosed |
| EP-1869043-A2 | PYRAZOLOPYRIDINE-1,4-DIAMINES AND ANALOGS THEREOF | Coley Pharmaceutical Group, Inc. (US) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006107853-A2 | PYRAZOLOPYRIDINE-1,4-DIAMINES AND ANALOGS THEREOF | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2006-10-12 | — | — | WO | disclosed |