Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | F12 | P00748 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19010905 | 0.88 | TP53 (0.60) | NPC1RAB9ASMN1; SMN2TP53L3MBTL1 | |
| SCHEMBL19543318 | 0.82 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2TP53L3MBTL1 | |
| SCHEMBL19010910 | 0.80 | RAB9A (0.62) | NPC1RAB9ASMN1; SMN2TP53L3MBTL1 | |
| SCHEMBL31280939 | 0.77 | RAB9A (0.56) | NPC1RAB9ASMN1; SMN2TP53L3MBTL1 | |
| SCHEMBL7563886 | 0.77 | RAB9A (0.56) | NPC1RAB9ASMN1; SMN2TP53L3MBTL1 | |
| SCHEMBL19010904 | 0.77 | ADRB2 (0.50) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL149306 | 0.77 | KDM4E (0.54) | NPC1RAB9ASMN1; SMN2TP53L3MBTL1 | |
| SCHEMBL19010926 | 0.76 | NPC1 (0.70) | NPC1RAB9ASMN1; SMN2TP53MAPT | |
| SCHEMBL20390788 | 0.73 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2TP53L3MBTL1 | |
| SCHEMBL19010901 | 0.71 | TP53 (0.60) | NPC1RAB9ASMN1; SMN2TP53L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180135121-A1 | PORE-FORMING PROTEIN CONJUGATE COMPOSITIONS AND METHODS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-05-17 | — | — | US | disclosed |
| US-9890426-B2 | Pore-forming protein conjugate compositions and methods | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-02-13 | — | — | US | disclosed |
| US-20170175183-A1 | PORE-FORMING PROTEIN CONJUGATE COMPOSITIONS AND METHODS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170175183-A1 | PORE-FORMING PROTEIN CONJUGATE COMPOSITIONS AND METHODS | TIAL1, NUP93, PORCN | NPC1 352/4885RAB9A 525/4885SMN1; SMN2 4764/4885 |
| US-20180135121-A1 | PORE-FORMING PROTEIN CONJUGATE COMPOSITIONS AND METHODS | TIAL1, NUP93, PORCN | NPC1 351/4885RAB9A 540/4885SMN1; SMN2 4763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.