Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 4/20 | 0.35 |
| ▸ | TNK2 | Q07912 | 4/20 | 0.35 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.34 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | HPGD | P15428 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | CASP1 | P29466 | 2/20 | 0.33 |
| ▸ | CASP7 | P55210 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1898806 | 0.94 | HSD17B10 (0.39) | LCKTNK2KCNQ3KCNQ2ALDH1A1 | |
| SCHEMBL1900099 | 0.93 | LCK (0.35) | LCKTNK2MERTKEGFRKDR | |
| SCHEMBL1908428 | 0.87 | MERTK (0.35) | LCKTNK2MERTKALDH1A1HPGD | |
| SCHEMBL1900820 | 0.84 | MERTK (0.34) | LCKTNK2MERTKALDH1A1HPGD | |
| SCHEMBL1905820 | 0.82 | ALDH1A1 (0.39) | LCKTNK2KCNQ3KCNQ2MERTK | |
| SCHEMBL1905199 | 0.82 | AKT1 (0.43) | AKT1AKT2 | |
| SCHEMBL1905018 | 0.79 | EGFR (0.34) | LCKTNK2MERTKALDH1A1HPGD | |
| SCHEMBL1899937 | 0.77 | AKT1 (0.42) | AKT1AKT2 | |
| SCHEMBL1904913 | 0.76 | ALDH1A1 (0.41) | LCKTNK2KCNQ3KCNQ2ALDH1A1 | |
| SCHEMBL12095366 | 0.76 | KDM4E (0.37) | LCKTNK2MERTKALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011055115-A1 | AKT / PKB INHIBITORS | ALMAC DISCOVERY LIMITED (GB) | 2011-05-12 | — | — | WO | disclosed |