Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 11/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1093907 | 0.93 | TLR8 (0.47) | TLR8TLR7HPGDL3MBTL1MEN1 | |
| SCHEMBL1094849 | 0.81 | NFKB1 (0.32) | — | |
| SCHEMBL3021829 | 0.75 | TLR8 (0.56) | TLR8TLR7HPGDMEN1KMT2A | |
| SCHEMBL1901276 | 0.73 | TLR8 (0.53) | TLR8TLR7CNR2 | |
| SCHEMBL18297270 | 0.69 | TLR8 (0.47) | TLR8TLR7HPGDL3MBTL1MEN1 | |
| SCHEMBL28265084 | 0.67 | TLR8 (0.52) | TLR8TLR7MEN1KMT2A | |
| SCHEMBL1093906 | 0.67 | TLR8 (0.56) | TLR8TLR7HPGDL3MBTL1MEN1 | |
| SCHEMBL22790540 | 0.66 | TLR8 (0.72) | TLR8TLR7 | |
| SCHEMBL1656313 | 0.65 | TLR8 (0.69) | TLR8TLR7 | |
| SCHEMBL28145441 | 0.64 | TLR8 (0.43) | TLR8TLR7HPGDL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3081558-A1 | 8-SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS | Array Biopharma, Inc. (US) | 2016-10-19 | — | — | EP | disclosed |
| US-20120165317-A1 | 8-SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS | ARRAY BIOPHARMA INC. (US) | 2012-06-28 | — | — | US | disclosed |
| EP-2322510-A2 | 8-substituted benzoazepines as toll-like receptor modulators | Array Biopharma, Inc. (US) | 2011-05-18 | — | — | EP | disclosed |
| US-20080234251-A1 | 8-Substituted Benzoazepines as Toll-Like Receptor Modulators | ARRAY BIOPHARMA INC. (US) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165317-A1 | 8-SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS | TLR8, TLR7, TLR9 | TLR8 1/4885TLR7 2/4885HPGD 4336/4885 |
| US-20080234251-A1 | 8-Substituted Benzoazepines as Toll-Like Receptor Modulators | TLR8, TLR7, TLR9 | TLR8 1/4885TLR7 2/4885HPGD 4336/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.