Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1A1 | Q02108 | 4/20 | 0.41 |
| ▸ | GUCY1B1 | Q02153 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 2/20 | 0.38 |
| ▸ | MGLL | Q99685 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | QDPR | P09417 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17395670 | 0.84 | MGLL (0.40) | CYP3A4CYP2C9SLC9A1MGLLDRD2 | |
| SCHEMBL20847810 | 0.83 | HSD17B10 (0.53) | CCR1ADAMTS5 | |
| SCHEMBL17397714 | 0.82 | TDP1 (0.47) | GUCY1A1GUCY1B1CYP3A4CYP2C9SLC9A1 | |
| SCHEMBL2480697 | 0.79 | CYP3A4 (0.48) | CYP3A4CYP2C9SLC9A1PDE4BNAMPT | |
| SCHEMBL19013103 | 0.78 | MAPT (0.50) | CYP3A4CYP2C9 | |
| SCHEMBL17398252 | 0.75 | MGLL (0.41) | SLC9A1MGLLDRD2DRD3 | |
| SCHEMBL3143892 | 0.74 | NUDT1 (0.40) | DRD2DRD3 | |
| SCHEMBL19012974 | 0.74 | ADAMTS5 (0.43) | GUCY1A1GUCY1B1CYP3A4CYP2C9SLC9A1 | |
| SCHEMBL28134205 | 0.72 | SLC6A2 (0.43) | QDPR | |
| SCHEMBL3809683 | 0.72 | ESR2 (0.51) | CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017103888-A1 | INDANE DERIVATIVES AND THE USE THEREOF AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | NOVARTIS AG (CH) | 2017-06-22 | — | — | WO | disclosed |