Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.61 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.57 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.56 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.55 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.55 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.55 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CKS1B | P61024 | 1/20 | 0.49 |
| ▸ | SKP1 | P63208 | 1/20 | 0.49 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.47 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.47 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29319392 | 0.86 | ACHE (0.60) | ACHECHRNA7PTPN11GPR119DDB1 | |
| SCHEMBL15286547 | 0.86 | ACHE (0.62) | ACHECHRNA7PTPN11GPR119DDB1 | |
| SCHEMBL30166226 | 0.85 | ACHE (0.61) | ACHECHRNA7PTPN11GPR119DDB1 | |
| SCHEMBL1433109 | 0.85 | ACHE (0.61) | ACHECHRNA7PTPN11GPR119DDB1 | |
| SCHEMBL25239206 | 0.84 | ACHE (0.61) | ACHECHRNA7PTPN11GPR119DDB1 | |
| SCHEMBL15740635 | 0.84 | GPR119 (0.48) | ACHECHRNA7PTPN11GPR119DDB1 | |
| SCHEMBL25237476 | 0.84 | ACHE (0.60) | ACHECHRNA7PTPN11GPR119DDB1 | |
| SCHEMBL7136906 | 0.84 | ACHE (0.63) | ACHECHRNA7PTPN11GPR119DDB1 | |
| SCHEMBL25242301 | 0.83 | ACHE (0.57) | ACHECHRNA7PTPN11GPR119DDB1 | |
| SCHEMBL29319390 | 0.83 | ACHE (0.57) | ACHECHRNA7PTPN11GPR119DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3181564-B1 | AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS | HOFFMANN LA ROCHE (CH) | 2019-09-18 | — | — | EP | disclosed |
| US-9890152-B2 | Aminopyrimidine compounds as inhibitors of T790M containing EGFR mutants | GENENTECH, INC. (US) | 2018-02-13 | — | — | US | disclosed |
| EP-2922851-B1 | AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS | GENENTECH INC (US) | 2017-07-26 | — | — | EP | disclosed |
| EP-3181564-A1 | AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS | Genentech, Inc. (US) | 2017-06-21 | — | — | EP | disclosed |