SCHEMBL1901698

SCHEMBL1901698

C=CC(=O)NC(C)(CC)C(C)C(C)=O

nearest known ligand 0.38

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.38
ALDH1A1 P00352 2/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
ZDHHC20 Q5W0Z9 1/20 0.36
ZDHHC2 Q9UIJ5 1/20 0.36
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
MAPK1 P28482 1/20 0.32
TDP1 Q9NUW8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8765961 0.84 TSHR (0.42) TSHRALDH1A1CYP3A4CYP2C9CYP2C19
SCHEMBL21728849 0.79 TSHR (0.38) TSHRALDH1A1CYP3A4CYP2C9CYP2C19
SCHEMBL2724364 0.78 ALDH1A1 (0.40) TSHRALDH1A1CYP3A4CYP2C9CYP2C19
SCHEMBL2559057 0.77 TSHR (0.36) TSHRALDH1A1CYP3A4CYP2C9CYP2C19
SCHEMBL11380983 0.77 TSHR (0.36) TSHRALDH1A1CYP3A4CYP2C9CYP2C19
SCHEMBL11863529 0.76 ALDH1A1 (0.37) TSHRALDH1A1CYP3A4CYP2C9CYP2C19
SCHEMBL137801 0.76 TSHR (0.45) TSHRALDH1A1CYP3A4CYP2C9CYP2C19
SCHEMBL28308530 0.74 TSHR (0.43) TSHRALDH1A1CYP3A4CYP2C9CYP2C19
SCHEMBL29192563 0.74 TSHR (0.39) TSHRALDH1A1CYP3A4CYP2C9CYP2C19
SCHEMBL28899828 0.72 TSHR (0.45) TSHRALDH1A1CYP3A4CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6686321-B2 MIXTURE; LUBRICANT OIL ADDITIVE CASTROL LIMITED (GB) 2004-02-03 US claimed
EP-1432747-B1 MULTIFUNCTIONAL VISCOSITY INDEX IMPROVER AND DISPERSANT CHEMTURA CORP (US) 2011-05-11 EP disclosed
CN-1293110-C Multifunctional viscosity index improver and dispersant CROMPTON CORP (US) 2007-01-03 CN disclosed
US-7144951-B2 Multifunctional viscosity index improver and dispersant CROMPTON CORPORATION (US) 2006-12-05 US disclosed
CN-1261550-C Viscosity growth inhibition in oil additive concentrates CROMPTON CORP (US) 2006-06-28 CN disclosed
EP-1446466-B1 VISCOSITY GROWTH INHIBITION IN OIL ADDITIVE CONCENTRATES CHEMTURA CORP (US) 2006-06-21 EP disclosed
CN-1596296-A Viscosity growth inhibition in oil additive concentrates CROMPTON CORP (US) 2005-03-16 CN disclosed
CN-1545527-A Multifunctional viscosity index improver and dispersant ��³�նٹ�˾ 2004-11-10 CN disclosed
US-20040186238-A1 Multifunctional viscosity index improver and dispersant WEBER CITY ROAD LLC 2004-09-23 US disclosed
EP-1446466-A1 VISCOSITY GROWTH INHIBITION IN OIL ADDITIVE CONCENTRATES Crompton Corporation (US) 2004-08-18 EP disclosed
EP-0208525-A2 Use of olefin polymer viscosity index improver additive in oil compositions EXXON CHEMICAL PATENTS INC. (US) 1987-01-14 EP disclosed
US-4611031-A Process for the preparation of a compatibilizer for concentrated polymer blends and compatibilizer product ROHM AND HAAS COMPANY (US) 1986-09-09 US disclosed
EP-0193272-A2 Preparation of a graft-copolymeric compatibilizer useful as an oil additive ROHM AND HAAS COMPANY (US) 1986-09-03 EP disclosed
EP-0171167-A2 Process for preparation of oil compositions comprising a viscosity index improver-dispersant additive EXXON RESEARCH AND ENGINEERING COMPANY (US) 1986-02-12 EP disclosed
US-4434064-A GRINDING WITH OXYGEN ATLANTIC RICHFIELD COMPANY (US) 1984-02-28 US disclosed
US-4417991-A NONTHICKENING, EXTREME PRESSURE LUBRICANTS ATLANTIC RICHFIELD COMPANY (US) 1983-11-29 US disclosed
US-4411804-A CONTAINING GRAPHITE, MOLYBDENUM DISULFIDE, OR ZINC OXIDE AND FLOW CONTROL AGENT ATLANTIC RICHFIELD COMPANY (US) 1983-10-25 US disclosed
US-4146489-A LUBRICANTS, DISPERSANTS ROHM AND HAAS COMPANY (US) 1979-03-27 US disclosed
US-4132656-A OLEFIN-DIALKYLAMINOALKYL METHACRYLATE POLYMER; OR ALKYL METHACRYLATE-DIALKYLAMINOALKYL METHACRYLATE OR N(ALKANONE) ACRYLAMIDE POLYMER AS ANTIDEPOSIT AGENT ATLANTIC RICHFIELD COMPANY (US) 1979-01-02 US disclosed
US-3941836-A SOLUBILIZERS, PLASTICIZER, UV ABSORBER THE LUBRIZOL CORPORATION (US) 1976-03-02 US disclosed