Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.48 |
| ▸ | JAK1 | P23458 | 11/20 | 0.47 |
| ▸ | JAK3 | P52333 | 8/20 | 0.47 |
| ▸ | TYK2 | P29597 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 3/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.46 |
| ▸ | PAK4 | O96013 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | LTK | P29376 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL101593 | 0.86 | JAK2 (0.62) | JAK2HDAC6HDAC1JAK1JAK3 | |
| Phosphoric Acid SCHEMBL28297504 | 0.80 | JAK2 (0.61) | JAK2HDAC6HDAC1JAK1JAK3 | |
| Trifluoroacetic Acid SCHEMBL860379 | 0.77 | JAK2 (0.60) | JAK2HDAC6HDAC1JAK1JAK3 | |
| SCHEMBL13695723 | 0.72 | JAK2 (0.65) | JAK2HDAC6HDAC1JAK1JAK3 | |
| SCHEMBL20908684 | 0.70 | JAK2 (0.69) | JAK2HDAC6HDAC1JAK1JAK3 | |
| SCHEMBL13678278 | 0.70 | JAK2 (0.53) | JAK2HDAC6HDAC1JAK1JAK3 | |
| SCHEMBL28049773 | 0.70 | JAK2 (0.53) | JAK2HDAC6JAK1JAK3TYK2 | |
| SCHEMBL27210103 | 0.70 | JAK2 (0.58) | JAK2HDAC6HDAC1JAK1JAK3 | |
| SCHEMBL17907476 | 0.70 | JAK2 (0.54) | JAK2HDAC6HDAC1JAK1JAK3 | |
| SCHEMBL13774665 | 0.70 | JAK2 (0.61) | JAK2HDAC6HDAC1JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3184526-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS JANUS KINASE INHIBITOR | Incyte Holdings Corporation (US) | 2017-06-28 | — | — | EP | disclosed |