Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD40 | P25942 | 4/20 | 0.69 |
| ▸ | CD40LG | P29965 | 4/20 | 0.69 |
| ▸ | TTR | P02766 | 1/20 | 0.48 |
| ▸ | FABP4 | P15090 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.46 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | ATIC | P31939 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19020634 | 0.95 | CD40 (0.77) | CD40CD40LGTTRFABP4CCNA2 | |
| SCHEMBL11435576 | 0.84 | CD40 (0.50) | CD40CD40LGTTRFABP4CCNA2 | |
| SCHEMBL11500762 | 0.84 | CD40 (0.53) | CD40CD40LGTTRFABP4CCNA2 | |
| SCHEMBL19021224 | 0.83 | CD40 (0.92) | CD40CD40LGTTRFABP4CCNA2 | |
| SCHEMBL11436100 | 0.83 | CD40 (0.49) | CD40CD40LGHDAC1HPGDSMN1; SMN2 | |
| SCHEMBL6242038 | 0.83 | CD40 (0.61) | CD40CD40LGTTRFABP4CCNA2 | |
| SCHEMBL19020632 | 0.82 | CD40 (1.00) | CD40CD40LGTTRFABP4CCNA2 | |
| SCHEMBL23735897 | 0.81 | HDAC1 (0.50) | CD40CD40LGHDAC1SETD7PRMT1 | |
| SCHEMBL11758756 | 0.80 | TIMP3 (0.54) | CD40CD40LGTTRPRMT1HPGD | |
| SCHEMBL20590980 | 0.80 | CD40 (1.00) | CD40CD40LGSMN1; SMN2MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3389781-B1 | INHIBITORS OF TNF SUPERFAMILY COSTIMULATORY INTERACTIONS AND METHODS FOR USES OF THE SAME | UNIV MIAMI (US) | 2021-08-11 | — | — | EP | disclosed |
| EP-3389781-B1 | INHIBITORS OF TNF SUPERFAMILY COSTIMULATORY INTERACTIONS AND METHODS FOR USES OF THE SAME | UNIV MIAMI (US) | 2021-08-11 | — | — | EP | disclosed |
| US-10562848-B2 | Inhibitors of TNF superfamily costimulatory interactions and methods for uses of the same | UNIVERSITY OF MIAMI (US) | 2020-02-18 | — | — | US | disclosed |
| US-10562848-B2 | Inhibitors of TNF superfamily costimulatory interactions and methods for uses of the same | UNIVERSITY OF MIAMI (US) | 2020-02-18 | — | — | US | disclosed |
| US-20180370909-A1 | INHIBITORS OF TNF SUPERFAMILY COSTIMULATORY INTERACTIONS AND METHODS FOR USES OF THE SAME | UNIVERSITY OF MIAMI (US) | 2018-12-27 | — | — | US | disclosed |
| WO-2017106436-A1 | INHIBITORS OF TNF SUPERFAMILY COSTIMULATORY INTERACTIONS AND METHODS FOR USES OF THE SAME | UNIVERSITY OF MIAMI (US) | 2017-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180370909-A1 | INHIBITORS OF TNF SUPERFAMILY COSTIMULATORY INTERACTIONS AND METHODS FOR USES OF THE SAME | CD40, TNFRSF9, TNFRSF1A | CD40 1/4885CD40LG 7/4885TTR 2920/4885 |
| US-10562848-B2 | Inhibitors of TNF superfamily costimulatory interactions and methods for uses of the same | CD40, TNFRSF9, TNFRSF1A | CD40 1/4885CD40LG 7/4885TTR 2920/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.