Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | MC4R | P32245 | 6/20 | 0.40 |
| ▸ | GRM5 | P41594 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MC3R | P41968 | 3/20 | 0.39 |
| ▸ | DRD5 | P21918 | 2/20 | 0.38 |
| ▸ | MC5R | P33032 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4609788 | 0.81 | ME2 (0.43) | KDM4ESMN1; SMN2DRD4DRD2DRD3 | |
| SCHEMBL4610865 | 0.81 | IDO1 (0.42) | DRD2DRD3GRM5SLC6A2SLC6A4 | |
| SCHEMBL4608750 | 0.81 | GRM5 (0.56) | GRM5SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4608926 | 0.80 | SLC6A2 (0.43) | DRD4DRD2GRM5SLC6A2SLC6A4 | |
| SCHEMBL1902180 | 0.79 | KMT2A (0.42) | KDM4EDRD4DRD2MC4RGRM5 | |
| SCHEMBL4608428 | 0.78 | SLC6A2 (0.46) | MC4RGRM5SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4609000 | 0.78 | SLC6A2 (0.43) | MC4RGRM5NPC1RAB9ASLC6A2 | |
| SCHEMBL4610300 | 0.78 | GRM5 (0.40) | SMN1; SMN2DRD2GRM5ALDH1A1MAPT | |
| SCHEMBL4610088 | 0.77 | SLC6A2 (0.43) | DRD4DRD3GRM5DRD5SLC6A2 | |
| SCHEMBL4610103 | 0.77 | GRM5 (0.59) | SMN1; SMN2DRD4DRD2DRD3GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979320-A2 | PIPERAZINES AND PIPERIDINES AS mGluR5 POTENTIATORS | AstraZeneca AB (SE) | 2008-10-15 | — | — | EP | claimed |
| WO-2007087135-A2 | PIPERAZINES AND PIPERIDINES AS mGluR5 POTENTIATORS | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | WO | claimed |