Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26343641 | 0.85 | ALDH1A1 (0.43) | ALDH1A1KMT2APOLBMCL1SMN1; SMN2 | |
| SCHEMBL20960384 | 0.83 | HPGD (0.45) | ALDH1A1KMT2AMAPK1GAASIGMAR1 | |
| SCHEMBL15630655 | 0.83 | HPGD (0.45) | ALDH1A1KMT2AMAPK1GAASIGMAR1 | |
| SCHEMBL19022024 | 0.82 | ALDH1A1 (0.38) | ALDH1A1KMT2APOLBMCL1SMN1; SMN2 | |
| SCHEMBL16900211 | 0.81 | GAA (0.44) | ALDH1A1KMT2ASMN1; SMN2GAASIGMAR1 | |
| SCHEMBL19009040 | 0.80 | ALDH1A1 (0.34) | ALDH1A1KMT2APOLBMCL1SMN1; SMN2 | |
| SCHEMBL18743860 | 0.78 | ALDH1A1 (0.38) | ALDH1A1KMT2APOLBMCL1SMN1; SMN2 | |
| SCHEMBL16900219 | 0.76 | ALDH1A1 (0.42) | ALDH1A1KMT2ASMN1; SMN2GAASIGMAR1 | |
| SCHEMBL19000014 | 0.76 | CHRM5 (0.54) | ALDH1A1KMT2APOLBSMN1; SMN2GAA | |
| SCHEMBL8023138 | 0.74 | ALDH1A1 (0.67) | ALDH1A1KMT2APOLBSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017106607-A1 | POLYCYCLIC TLR7/8 ANTAGONISTS AND USE THEREOF IN THE TREATMENT OF IMMUNE DISORDERS | MERCK PATENT GMBH (DE) | 2017-06-22 | — | — | WO | disclosed |