Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLP1R | P43220 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30872394 | 0.83 | GLP1R (0.41) | GLP1R | |
| SCHEMBL10669992 | 0.76 | CYP3A4 (0.33) | — | |
| SCHEMBL25379591 | 0.69 | GABRA2 (0.33) | — | |
| SCHEMBL30755644 | 0.69 | — | — | |
| SCHEMBL19024357 | 0.68 | HPGD (0.31) | — | |
| SCHEMBL24602698 | 0.67 | XPO1 (0.33) | — | |
| SCHEMBL30911120 | 0.67 | ENPP1 (0.41) | GLP1R | |
| SCHEMBL7111689 | 0.66 | ALDH1A1 (0.37) | — | |
| SCHEMBL5946432 | 0.64 | CYP3A4 (0.40) | — | |
| SCHEMBL31047289 | 0.64 | GABRA2 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11634410-B2 | Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors | PFIZER INC. (US) | 2023-04-25 | — | — | US | disclosed |
| US-20210309644-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | PFIZER INC. (US) | 2021-10-07 | — | — | US | disclosed |
| US-10988463-B2 | Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors | PFIZER INC. (US) | 2021-04-27 | — | — | US | disclosed |
| EP-3397631-B1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | PFIZER (US) | 2021-04-07 | — | — | EP | disclosed |
| US-20200377482-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | PFIZER INC. (US) | 2020-12-03 | — | — | US | disclosed |
| CN-108473469-B | Substituted 3-azabicyclo [3.1.0] hexanes as ketohexokinase inhibitors | 辉瑞公司 | 2020-11-03 | — | — | CN | disclosed |
| US-10787438-B2 | Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors | PFIZER INC. (US) | 2020-09-29 | — | — | US | disclosed |
| US-20200148669-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | PFIZER INC. (US) | 2020-05-14 | — | — | US | disclosed |
| US-20190106412-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | PFIZER INC. (US) | 2019-04-11 | — | — | US | disclosed |
| US-10174007-B2 | Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors | PFIZER INC. (US) | 2019-01-08 | — | — | US | disclosed |
| US-20180037575-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | PFIZER INC. | 2018-02-08 | — | — | US | disclosed |
| US-9809579-B2 | Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors | PFIZER INC. (US) | 2017-11-07 | — | — | US | disclosed |
| US-20170183328-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | PFIZER INC. | 2017-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200148669-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | HK1, GCK, KHK | GLP1R 2839/4885 |
| US-20210309644-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | HK1, GCK, KHK | GLP1R 2839/4885 |
| US-11634410-B2 | Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors | HK1, GCK, KHK | GLP1R 2839/4885 |
| US-10988463-B2 | Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors | HK1, GCK, KHK | GLP1R 2839/4885 |
| US-20170183328-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | HK1, GCK, KHK | GLP1R 2839/4885 |
| US-20190106412-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | HK1, GCK, KHK | GLP1R 2839/4885 |
| US-20200377482-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | HK1, GCK, KHK | GLP1R 2839/4885 |
| US-20180037575-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | HK1, GCK, KHK | GLP1R 2839/4885 |
| US-10174007-B2 | Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors | HK1, GCK, KHK | GLP1R 2839/4885 |
| US-10787438-B2 | Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors | HK1, GCK, KHK | GLP1R 2839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.