Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 19/20 | 0.84 |
| ▸ | CYP2C9 | P11712 | 10/20 | 0.84 |
| ▸ | CYP2C19 | P33261 | 9/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1029194 | 1.00 | HSD11B1 (0.84) | HSD11B1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL1029191 | 1.00 | HSD11B1 (0.84) | HSD11B1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL117891 | 0.91 | HSD11B1 (1.00) | HSD11B1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL26688568 | 0.91 | HSD11B1 (1.00) | HSD11B1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL117892 | 0.91 | HSD11B1 (1.00) | HSD11B1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL23798791 | 0.91 | HSD11B1 (1.00) | HSD11B1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL1906511 | 0.91 | HSD11B1 (0.73) | HSD11B1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL23798790 | 0.91 | HSD11B1 (1.00) | HSD11B1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL12670499 | 0.91 | HSD11B1 (0.73) | HSD11B1CYP2C9CYP2C19CYP3A4 | |
| Water SCHEMBL15153126 | 0.91 | HSD11B1 (0.98) | HSD11B1CYP2C9CYP2C19CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274287-B1 | INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | VITAE PHARMACEUTICALS INC (US) | 2016-03-09 | — | — | EP | disclosed |
| EP-2274287-B1 | INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | VITAE PHARMACEUTICALS INC (US) | 2016-03-09 | — | — | EP | disclosed |
| US-20110105504-A1 | Inhibitors Of 11beta-Hydroxysteroid Dehydrogenase Type 1 | Vitae Pharmaceuticals ,Inc. | 2011-05-05 | — | — | US | disclosed |
| US-20110105504-A1 | Inhibitors Of 11beta-Hydroxysteroid Dehydrogenase Type 1 | Vitae Pharmaceuticals ,Inc. | 2011-05-05 | — | — | US | disclosed |
| US-20110105504-A1 | Inhibitors Of 11beta-Hydroxysteroid Dehydrogenase Type 1 | Vitae Pharmaceuticals ,Inc. | 2011-05-05 | — | — | US | disclosed |
| WO-2009117109-A1 | INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105504-A1 | Inhibitors Of 11beta-Hydroxysteroid Dehydrogenase Type 1 | HSD11B1, HSD17B1, HSD11B2 | HSD11B1 1/4885CYP2C9 184/4885CYP2C19 115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.