Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.60 |
| ▸ | FBP1 | P09467 | 2/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | INSR | P06213 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | FLT4 | P35916 | 1/20 | 0.54 |
| ▸ | CLK1 | P49759 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19026693 | 0.90 | EGFR (0.74) | EGFRERBB2FBP1HDAC3HDAC4 | |
| SCHEMBL19027000 | 0.89 | EGFR (0.58) | EGFRERBB2FBP1KDR | |
| SCHEMBL19125553 | 0.88 | EGFR (0.63) | EGFRERBB2FBP1HDAC3HDAC4 | |
| SCHEMBL17538524 | 0.85 | FBP1 (0.59) | EGFRERBB2FBP1KDRAURKA | |
| SCHEMBL18632967 | 0.85 | FBP1 (0.76) | EGFRERBB2FBP1KDRAURKA | |
| SCHEMBL17538523 | 0.83 | EGFR (0.58) | EGFRERBB2FBP1KDRAURKA | |
| SCHEMBL18862875 | 0.83 | EGFR (0.75) | EGFRERBB2FBP1HDAC3HDAC4 | |
| SCHEMBL17538486 | 0.82 | EGFR (0.85) | EGFRERBB2 | |
| SCHEMBL21761244 | 0.82 | EGFR (0.63) | EGFRERBB2FBP1KDRAURKA | |
| SCHEMBL18862786 | 0.80 | EGFR (0.77) | EGFRERBB2KDRPDGFRBFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3181553-A1 | QUINAZOLINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | Arromax Pharmatech Co., Ltd. (CN) | 2017-06-21 | — | — | EP | disclosed |