Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 2/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1895693 | 0.86 | CDC7 (0.46) | CDC7IRAK4MKNK1MKNK2MAPT | |
| SCHEMBL1897939 | 0.83 | CDC7 (0.41) | CDC7DPP4MKNK1MKNK2MAPT | |
| SCHEMBL1896821 | 0.81 | CDC7 (0.58) | CDC7IRAK4MAPTCDK2MAP4K4 | |
| SCHEMBL1894817 | 0.77 | MKNK1 (0.47) | MKNK1MKNK2KDR | |
| SCHEMBL1224863 | 0.75 | LMNA (0.40) | IRAK4DPP4MAPT | |
| SCHEMBL13556203 | 0.75 | GPR119 (0.44) | IRAK4DPP4FYNMKNK1MKNK2 | |
| SCHEMBL1897869 | 0.75 | RAB9A (0.42) | MAPTCDK2KDRCSNK2A1 | |
| SCHEMBL1896942 | 0.72 | CDC7 (0.62) | CDC7CDK2 | |
| SCHEMBL13556113 | 0.70 | CDC7 (0.43) | CDC7MKNK1MKNK2MAPTCDK2 | |
| SCHEMBL13556184 | 0.70 | MAPT (0.43) | CDC7MKNK1MKNK2MAPTCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8765749-B2 | 1,6-disubstituted indole compounds as protein kinase inhibitors | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2014-07-01 | — | — | US | disclosed |
| US-8765749-B2 | 1,6-disubstituted indole compounds as protein kinase inhibitors | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2014-07-01 | — | — | US | disclosed |
| US-8765749-B2 | 1,6-disubstituted indole compounds as protein kinase inhibitors | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2014-07-01 | — | — | US | disclosed |
| US-20120271048-A1 | NOVEL 1,6-DISUBSTITUTED INDOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2012-10-25 | — | — | US | disclosed |
| US-20120271048-A1 | NOVEL 1,6-DISUBSTITUTED INDOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2012-10-25 | — | — | US | disclosed |
| WO-2011052923-A2 | NOVEL 1,6-DISUBSTITUTED INDOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2011-05-05 | — | — | WO | disclosed |
| WO-2011052923-A2 | NOVEL 1,6-DISUBSTITUTED INDOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2011-05-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120271048-A1 | NOVEL 1,6-DISUBSTITUTED INDOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS | MAP3K6, MAP3K20, MAP3K1 | CDC7 275/4885IRAK4 1183/4885DPP4 3576/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.