Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B known ✓ | P49841 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MMP3 | P08254 | 1/20 | 0.56 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | KMO | O15229 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL1839538 | 1.00 | ALDH1A1 (0.69) | ALDH1A1MAPTSMN1; SMN2MMP3BCL2L1 | |
| Biphenyl SCHEMBL377457 | 1.00 | ALDH1A1 (0.69) | ALDH1A1MAPTSMN1; SMN2MMP3BCL2L1 | |
| Biphenyl SCHEMBL750993 | 1.00 | ALDH1A1 (0.69) | ALDH1A1MAPTSMN1; SMN2MMP3BCL2L1 | |
| Biphenyl SCHEMBL1396421 | 1.00 | ALDH1A1 (0.69) | ALDH1A1MAPTSMN1; SMN2MMP3BCL2L1 | |
| Biphenyl SCHEMBL6843734 | 0.96 | ALDH1A1 (0.64) | ALDH1A1MAPTSMN1; SMN2MMP3BCL2L1 | |
| Biphenyl SCHEMBL9412797 | 0.96 | ALDH1A1 (0.64) | ALDH1A1MAPTSMN1; SMN2MMP3BCL2L1 | |
| Tannin Pyrogallol SCHEMBL10431034 | 0.96 | ALDH1A1 (0.64) | ALDH1A1MAPTSMN1; SMN2MMP3BCL2L1 | |
| Biphenyl SCHEMBL5573670 | 0.93 | ALDH1A1 (0.60) | ALDH1A1MAPTSMN1; SMN2MMP3BCL2L1 | |
| Biphenyl SCHEMBL27463778 | 0.90 | SMN1; SMN2 (0.64) | ALDH1A1MAPTSMN1; SMN2MMP3BCL2L1 | |
| Biphenyl SCHEMBL10797777 | 0.89 | ALDH1A1 (0.64) | ALDH1A1MAPTSMN1; SMN2MMP3BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 453 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119798634-A | Polycarbonate resin material, and preparation method and application thereof | 宁波合裕新材料科技有限公司 | 2025-04-11 | — | — | CN | claimed |
| EP-3717447-B1 | PROCESS FOR THE PREPARATION OF ALKOXYLATES COMPOSITIONS | SPECIALTY OPERATIONS FRANCE (FR) | 2024-05-15 | — | — | EP | claimed |
| CN-220478125-U | Retrieve device of carbonic acid diphenyl sulfone catalyst | 江苏新瀚新材料股份有限公司 | 2024-02-13 | — | — | CN | claimed |
| CN-110628013-B | Bifunctional phosphorus-containing polyphenylene ether, and preparation method and application thereof | 河北健馨生物科技有限公司 | 2022-06-24 | — | — | CN | claimed |
| CN-110628013-A | Bifunctional phosphorus-containing polyphenylene ether, and preparation method and application thereof | 河北健馨生物科技有限公司 | 2019-12-31 | — | — | CN | claimed |
| CN-104900879-B | A kind of flame retardant type sodium-ion battery electrolyte and its application | 山东大学 | 2018-02-23 | — | — | CN | claimed |
| EP-2610291-B1 | GOLF BALL | DUNLOP SPORTS CO LTD (JP) | 2017-12-20 | — | — | EP | claimed |
| US-20160096914-A1 | URETHANES, POLYMERS THEREOF, COATING COMPOSITIONS AND THEIR PRODUCTION FROM CYCLIC CARBONATES | CYCLICOR AB (SE) | 2016-04-07 | — | — | US | claimed |
| EP-2997072-A1 | URETHANES, POLYMERS THEREOF, COATING COMPOSITIONS AND THEIR PRODUCTION FROM CYCLIC CARBONATES | Cyclicor AB (SE) | 2016-03-23 | — | — | EP | claimed |
| CN-105390649-A | LI-ION MONOBLOCK BATTERY FOR STOP/START APPLICATIONS | FORD GLOBAL TECH LLC | 2016-03-09 | — | — | CN | claimed |
| CN-101331168-A | Industrial production method for high-quality aromatic polycarbonate | ASAHI KASEI CHEMICALS CORP (JP) | 2008-12-24 | — | — | CN | claimed |
| EP-1536796-B1 | N-ARYL PIPERIDINE SUBSTITUTED BIPHENYLCARBOXAMIDES AS INHIBITORS OF APOLIPOPROTEIN B SECRETION | JANSSEN PHARMACEUTICA NV (BE) | 2008-02-13 | — | — | EP | claimed |
| EP-1379515-B1 | LIPID LOWERING BIPHENYLCARBOXAMIDES | JANSSEN PHARMACEUTICA NV (BE) | 2006-12-27 | — | — | EP | claimed |
| EP-1339685-B1 | BIPHENYLCARBOXAMIDES USEFUL AS LIPID LOWERING AGENTS | JANSSEN PHARMACEUTICA NV (BE) | 2006-11-02 | — | — | EP | claimed |
| WO-2003047750-A1 | OLEFIN EPOXIDATION WITH DUAL FUNCTIONAL CATALYST | HYDROCARBON TECHNOLOGIES, INC. (US) | 2003-06-12 | — | — | WO | claimed |
| CN-1412219-A | Method for producing polyester carbonic ester | BAYER AG (DE) | 2003-04-23 | — | — | CN | claimed |
| US-6534661-B1 | Porous particulate catalyst for selective in situ production of hydrogen peroxide from hydrogen and oxygen concurrent with olefin epoxidation, comprising epoxidation catalyst substrate with nanometer-sized crystallites of noble metal on surface | HYDROCARBON TECHNOLOGIES, INC. | 2003-03-18 | — | — | US | claimed |
| EP-0535261-A1 | Process for preparation of polycarbonate | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 1993-04-07 | — | — | EP | claimed |
| EP-0359037-A2 | Low-viscosity polyamide mouldings and mixtures | BAYER AG (DE) | 1990-03-21 | — | — | EP | claimed |
| US-4692170-A | ALKYL SUBSTITUTED PHENOLS AND PYROCATECHOLS, AROMATIC CARBONATES, AND 1,2-DIHYDROQUINOLINE POLYMERS | AGIP PETROLI, S.P.A. (IT) | 1987-09-08 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160096914-A1 | URETHANES, POLYMERS THEREOF, COATING COMPOSITIONS AND THEIR PRODUCTION FROM CYCLIC CARBONATES | UROD, PUF60, UTS2R | GSK3B 1790/4885ALDH1A1 2393/4885MAPT 498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.