Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B known ✓ | P49841 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MMP3 | P08254 | 1/20 | 0.53 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KMO | O15229 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL750993 | 0.96 | ALDH1A1 (0.69) | ALDH1A1MAPTSMN1; SMN2MMP3BCL2L1 | |
| Biphenyl SCHEMBL190337 | 0.96 | ALDH1A1 (0.69) | ALDH1A1MAPTSMN1; SMN2MMP3BCL2L1 | |
| Biphenyl SCHEMBL377457 | 0.96 | ALDH1A1 (0.69) | ALDH1A1MAPTSMN1; SMN2MMP3BCL2L1 | |
| Biphenyl SCHEMBL1396421 | 0.96 | ALDH1A1 (0.69) | ALDH1A1MAPTSMN1; SMN2MMP3BCL2L1 | |
| Biphenyl SCHEMBL1839538 | 0.96 | ALDH1A1 (0.69) | ALDH1A1MAPTSMN1; SMN2MMP3BCL2L1 | |
| Biphenyl SCHEMBL9412797 | 0.93 | ALDH1A1 (0.64) | ALDH1A1MAPTSMN1; SMN2MMP3BCL2L1 | |
| Tannin Pyrogallol SCHEMBL10431034 | 0.93 | ALDH1A1 (0.64) | ALDH1A1MAPTSMN1; SMN2MMP3BCL2L1 | |
| Biphenyl SCHEMBL5573670 | 0.90 | ALDH1A1 (0.60) | ALDH1A1MAPTSMN1; SMN2MMP3BCL2L1 | |
| Biphenyl SCHEMBL27463778 | 0.87 | SMN1; SMN2 (0.64) | ALDH1A1MAPTSMN1; SMN2MMP3BCL2L1 | |
| Biphenyl SCHEMBL10797777 | 0.86 | ALDH1A1 (0.64) | ALDH1A1MAPTSMN1; SMN2MMP3BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6767624-B2 | SOLID ALUMINUM CONTAINING ELECTROLYTE WITH A FILLER HAVING PARTICLE SIZE OF 1NM-20 MU M AND A POLYMERIC BINDER, AN ADHESION PROMOTING LAYER WITH THICKNESS OF < 100 MU M, AND A COMPONENET WITH ELECTROCHROMIC PROPERTIES | BASF AKTIENGESELLSCHAFT (DE) | 2004-07-27 | — | — | US | disclosed |
| US-20030031858-A1 | Solid aluminum containing electrolyte with a filler having particle size of 1nm-20 mu m and a polymeric binder, an adhesion promoting layer with thickness of < 100 mu m, and a componenet with electrochromic properties | BASF AKTIENGESELLSCHAFT (DE) | 2003-02-13 | — | — | US | disclosed |
| US-6361709-B1 | COMPRISED OF A POLYMERIC BINDER, FILLER, SALT, AND PLASTICIZER; GOOD CONDUCTIVITY AND TRANSPARENCY; FOR USE IN ELECTROCHROMIC GLAZING SYSTEMS | BASF AKTIENGESELLSCHAFT (DE) | 2002-03-26 | — | — | US | disclosed |