Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.56 |
| ▸ | MPI | P34949 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8691280 | 0.80 | CYP3A4 (0.45) | APLNRMPIALDH1A1TDP1CYP3A4 | |
| SCHEMBL7388303 | 0.78 | APLNR (0.58) | APLNRALDH1A1TDP1ABCB11NR3C1 | |
| SCHEMBL23577138 | 0.76 | APLNR (0.61) | APLNRALDH1A1TDP1ABCB11NR3C1 | |
| SCHEMBL21597747 | 0.76 | APLNR (0.56) | APLNRALDH1A1TDP1ABCB11NR3C1 | |
| SCHEMBL14257313 | 0.73 | APLNR (0.53) | APLNRALDH1A1TDP1ABCB11NR3C1 | |
| SCHEMBL29620864 | 0.73 | APLNR (0.53) | APLNRALDH1A1TDP1ABCB11NR3C1 | |
| SCHEMBL12189389 | 0.72 | — | — | |
| SCHEMBL2931701 | 0.72 | APLNR (0.43) | APLNRALDH1A1TDP1CYP3A4ALOX15 | |
| SCHEMBL6297258 | 0.72 | APLNR (0.44) | APLNRALDH1A1TDP1ABCB11NR3C1 | |
| SCHEMBL4726688 | 0.72 | ALDH1A1 (0.55) | APLNRALDH1A1TDP1ABCB11NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3148283-A | — | — | None | — | — | JP | disclosed |
| JP-3284684-A | — | — | None | — | — | JP | disclosed |
| EP-2013204-B1 | 2-AMINOPYRIDINE ANALOGS AS GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC (US) | 2015-02-18 | — | — | EP | disclosed |
| EP-2543667-B1 | A method of preparing 2-aminopyridine analogs as glucokinase activators | ARRAY BIOPHARMA INC (US) | 2015-01-28 | — | — | EP | disclosed |
| US-8933077-B2 | Glucokinase activators | ARRAY BIOPHARMA INC. (US) | 2015-01-13 | — | — | US | disclosed |
| US-8883828-B2 | 2-aminopyridine analogs as glucokinase activators | ARRAY BIOPHARMA INC. (US) | 2014-11-11 | — | — | US | disclosed |
| US-8883828-B2 | 2-aminopyridine analogs as glucokinase activators | ARRAY BIOPHARMA INC. (US) | 2014-11-11 | — | — | US | disclosed |
| EP-2543667-A9 | 2-aminopyridine analogs as glucokinase activators | Array Biopharma, Inc. (US) | 2013-08-21 | — | — | EP | disclosed |
| EP-2543667-A9 | 2-aminopyridine analogs as glucokinase activators | Array Biopharma, Inc. (US) | 2013-08-21 | — | — | EP | disclosed |
| US-20130065901-A1 | 2-AMINOPYRIDINE ANALOGS AS GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC. (US) | 2013-03-14 | — | — | US | disclosed |
| EP-1948652-A1 | GLUCOKINASE ACTIVATORS | Array Biopharma, Inc. (US) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007117381-A9 | 2 -AMINOPYRIDINE ANALOGS AS GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC (US) | 2008-03-27 | — | — | WO | disclosed |
| WO-2007117381-A2 | 2 -AMINOPYRIDINE ANALOGS AS GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC. (US) | 2007-10-18 | — | — | WO | disclosed |
| WO-2007089512-A1 | GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC. (US) | 2007-08-09 | — | — | WO | disclosed |
| WO-2007053345-A1 | GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC. (US) | 2007-05-10 | — | — | WO | disclosed |
| JP-H03284684-A | THIAZOLE DERIVATIVE AND ANTIULCER AGENT CONTAINING THE SAME | TERUMO CORP | 1991-12-16 | — | — | JP | disclosed |
| JP-H03148283-A | THIAZOLE DERIVATIVE OR ITS SALT AND ANTIULCER AGENT CONTAINING THE SAME | TERUMO CORP | 1991-06-25 | — | — | JP | disclosed |
| EP-0426574-A1 | Thiazole derivatives and antiulcer agents containing the same | TERUMO KABUSHIKI KAISHA (JP) | 1991-05-08 | — | — | EP | disclosed |
| EP-0426574-A1 | Thiazole derivatives and antiulcer agents containing the same | TERUMO KABUSHIKI KAISHA (JP) | 1991-05-08 | — | — | EP | disclosed |
| US-4891323-A | QUANTITATIVE ANALYSIS | OREAD LABORATORIES, INC. (US) | 1990-01-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130065901-A1 | 2-AMINOPYRIDINE ANALOGS AS GLUCOKINASE ACTIVATORS | GCK, GCKR, GALK1 | APLNR 2566/4885MPI 607/4885ALDH1A1 1205/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.