Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Monobenzone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 1/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | PTGS2 | P35354 | 1/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 1/20 | 1.00 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 1.00 |
| ▸ | GAA | P10253 | 3/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | BLM | P54132 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.69 |
| ▸ | ATM | Q13315 | 1/20 | 0.69 |
| ▸ | MAOB | P27338 | 4/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.67 |
| ▸ | MAOA | P21397 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Monobenzone SCHEMBL35631 | 1.00 | LMNA (1.00) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| Monobenzone SCHEMBL8450838 | 1.00 | LMNA (1.00) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| Monobenzone SCHEMBL11272996 | 1.00 | LMNA (1.00) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| Monobenzone SCHEMBL10803321 | 0.98 | LMNA (0.96) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| Monobenzone SCHEMBL10972560 | 0.98 | LMNA (0.96) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| Monobenzone SCHEMBL7511719 | 0.98 | LMNA (0.96) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| Monobenzone SCHEMBL9465511 | 0.96 | LMNA (0.92) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| Monobenzone SCHEMBL27401438 | 0.94 | LMNA (0.88) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL254671 | 0.94 | LMNA (0.88) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL2169314 | 0.94 | LMNA (0.88) | LMNACYP1A2PTGS1SLC6A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5639085-A | Light weight, soft feel hand ball | LISCO, INC. (US) | 1997-06-17 | — | — | US | claimed |
| US-11898054-B2 | Actinic radiation-curable urethane/urea-containing aerospace coatings and sealants | PRC-DESOTO INTERNATIONAL, INC. (US) | 2024-02-13 | — | — | US | disclosed |
| EP-3186299-B1 | POLYTHIOETHER SEALANTS WITH ENHANCED THERMAL RESISTANCE | PRC DESOTO INT INC (US) | 2021-05-12 | — | — | EP | disclosed |
| US-20210071032-A1 | ACTINIC RADIATION-CURABLE URETHANE/UREA-CONTAINING AEROSPACE COATINGS AND SEALANTS | PRC-DESOTO INTERNATIONAL, INC. | 2021-03-11 | — | — | US | disclosed |
| US-10883016-B2 | Actinic radiation-curable urethane/urea-containing aerospace coatings and sealants | PRC-DESOTO INTERNATIONAL, INC. (US) | 2021-01-05 | — | — | US | disclosed |
| EP-3497143-A1 | ACTINIC RADIATION-CURABLE URETHANE/UREA-CONTAINING AEROSPACE COATINGS AND SEALANTS | PRC-Desoto International, Inc. (US) | 2019-06-19 | — | — | EP | disclosed |
| US-20190169465-A1 | ACTINIC RADIATION-CURABLE URETHANE/UREA-CONTAINING AEROSPACE COATINGS AND SEALANTS | PRC-DESOTO INTERNATIONAL, INC. (US) | 2019-06-06 | — | — | US | disclosed |
| WO-2018031532-A1 | ACTINIC RADIATION-CURABLE URETHANE/UREA-CONTAINING AEROSPACE COATINGS AND SEALANTS | PRC-DESOTO INTERNATIONAL, INC. (US) | 2018-02-15 | — | — | WO | disclosed |
| CN-104220055-B | 4-oxo-2-pentenoic acid and skin pigmentation | 雀巢产品技术援助有限公司 | 2017-09-29 | — | — | CN | disclosed |
| EP-3186299-A1 | POLYTHIOETHER SEALANTS WITH ENHANCED THERMAL RESISTANCE | PRC-Desoto International, Inc. (US) | 2017-07-05 | — | — | EP | disclosed |
| EP-0235825-A2 | Alkenylated toluenediamines for use in preparing polyurethane/urea systems | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1987-09-09 | — | — | EP | disclosed |
| US-4624679-A | Compositions containing antimicorbial agents in combination with stabilizers | MORTON THIOKOL, INC. (US) | 1986-11-25 | — | — | US | disclosed |
| US-4616075-A | Storage of guayule by densification | THE FIRESTONE TIRE & RUBBER COMPANY (US) | 1986-10-07 | — | — | US | disclosed |
| EP-0075771-B1 | PHENOLS, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS STABILIZERS FOR POLYMERS | BAYER AG (DE) | 1986-04-09 | — | — | EP | disclosed |
| US-4568711-A | PARA-PHENYLENEDIAMINE, OPARA-DINITROSOARENE | THE FIRESTONE TIRE & RUBBER COMPANY (US) | 1986-02-04 | — | — | US | disclosed |
| US-4559378-A | GUAYLE RUBBER; SYNERGISTIC | THE FIRESTONE TIRE & RUBBER COMPANY (US) | 1985-12-17 | — | — | US | disclosed |
| US-4434265-A | STABILIZERS AGAINST OXIDATION OF OLEFIN POLYMERS | THE B.F. GOODRICH COMPANY (US) | 1984-02-28 | — | — | US | disclosed |
| EP-0075771-A1 | Phenols, process for their production and their use as stabilizers for polymers | BAYER AG (DE) | 1983-04-06 | — | — | EP | disclosed |
| US-4129597-A | Amino compounds and use thereof as antioxidants | PETROLITE CORPORATION (US) | 1978-12-12 | — | — | US | disclosed |
| US-3969315-A | Synergistic antioxidant combination of organic phosphite and amine | R. T. VANDERBILT COMPANY, INC. (US) | 1976-07-13 | — | — | US | disclosed |