Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Monobenzone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.88 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.88 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.88 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.88 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.88 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.88 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.88 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.88 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.88 |
| ▸ | MAOB | P27338 | 4/20 | 0.66 |
| ▸ | GAA | P10253 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.66 |
| ▸ | MAOA | P21397 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | BLM | P54132 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Monobenzone SCHEMBL11272996 | 0.94 | LMNA (1.00) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| Monobenzone SCHEMBL1903511 | 0.94 | LMNA (1.00) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| Monobenzone SCHEMBL8450838 | 0.94 | LMNA (1.00) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| Monobenzone SCHEMBL35631 | 0.94 | LMNA (1.00) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| Monobenzone SCHEMBL10803321 | 0.92 | LMNA (0.96) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| Monobenzone SCHEMBL10972560 | 0.92 | LMNA (0.96) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| Monobenzone SCHEMBL7511719 | 0.92 | LMNA (0.96) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| Monobenzone SCHEMBL9465511 | 0.90 | LMNA (0.92) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL254671 | 0.88 | LMNA (0.88) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL2169314 | 0.88 | LMNA (0.88) | LMNACYP1A2PTGS1SLC6A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1247509-C | Method for producing chroman | KURARAY CO (JP) | 2006-03-29 | — | — | CN | disclosed |
| CN-1394837-A | Method for producing chroman | KURARAY CO (JP) | 2003-02-05 | — | — | CN | disclosed |
| CN-1088066-C | Process for producing chromans | KURARAY CO (JP) | 2002-07-24 | — | — | CN | disclosed |
| CN-1206007-A | Process for producing chromans | KURARAY CO (JP) | 1999-01-27 | — | — | CN | disclosed |