Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.36 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HTR1B | P28222 | 1/20 | 0.31 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19035791 | 0.87 | PSMB1 (0.47) | PSMB1PSMB5PSMB2KDM4ELTA4H | |
| SCHEMBL19035793 | 0.86 | PSMB1 (0.49) | PSMB1PSMB5PSMB2KDM4EMEN1 | |
| SCHEMBL19035795 | 0.83 | ATM (0.42) | HRH3ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL19035792 | 0.77 | ALDH1A1 (0.41) | HRH3ALDH1A1PSMB1PSMB5PSMB2 | |
| SCHEMBL16605499 | 0.75 | ALDH1A1 (0.44) | HRH3ALDH1A1PAOXKDM4EDRD3 | |
| SCHEMBL11858444 | 0.73 | SLC18A3 (0.51) | HRH3ALDH1A1PAOXKDM4EDRD3 | |
| Hydrochloric Acid SCHEMBL27613307 | 0.72 | SLC18A3 (0.50) | HRH3ALDH1A1PAOXKDM4EDRD3 | |
| SCHEMBL24046182 | 0.71 | ALDH1A1 (0.35) | HRH3ALDH1A1PAOXKDM4EMEN1 | |
| SCHEMBL10174987 | 0.70 | ALDH1A1 (0.48) | HRH3ALDH1A1PAOXKDM4EDRD3 | |
| SCHEMBL17387575 | 0.69 | ALDH1A1 (0.54) | HRH3ALDH1A1PAOXKDM4EDRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9687548-B2 | Photoactivatable caged tamoxifen and tamoxifen derivative molecules and methods of use thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-06-27 | — | — | US | disclosed |