Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SCN1A | P35498 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19035791 | 0.84 | PSMB1 (0.47) | KMT2AMEN1SMN1; SMN2KDM4E | |
| SCHEMBL19035793 | 0.83 | PSMB1 (0.49) | KMT2AMEN1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL19035796 | 0.83 | HRH3 (0.40) | ALDH1A1KMT2AMEN1HRH3KDM4E | |
| SCHEMBL21303221 | 0.82 | GAA (0.42) | ATMALDH1A1L3MBTL1KMT2ALMNA | |
| SCHEMBL65772 | 0.75 | ATM (0.54) | ATMALDH1A1L3MBTL1KMT2ALMNA | |
| SCHEMBL15830173 | 0.75 | ATM (0.46) | ATMALDH1A1L3MBTL1KMT2ALMNA | |
| SCHEMBL19035792 | 0.75 | ALDH1A1 (0.41) | ALDH1A1L3MBTL1KMT2AMEN1KCNH2 | |
| SCHEMBL4184236 | 0.72 | ALDH1A1 (0.56) | ATMALDH1A1L3MBTL1KMT2ALMNA | |
| SCHEMBL13666861 | 0.72 | ATM (0.48) | ATMALDH1A1L3MBTL1KMT2ALMNA | |
| SCHEMBL7045906 | 0.72 | ALDH1A1 (0.44) | ALDH1A1LMNAGAASMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9687548-B2 | Photoactivatable caged tamoxifen and tamoxifen derivative molecules and methods of use thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-06-27 | — | — | US | disclosed |