Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10394340 | 0.75 | GAA (0.54) | YTHDC1GAA | |
| SCHEMBL10114441 | 0.74 | ALDH1A1 (0.76) | ALDH1A1SMN1; SMN2NPSR1KMT2ATP53 | |
| SCHEMBL19590970 | 0.72 | SMN1; SMN2 (0.44) | ALDH1A1SMN1; SMN2NPSR1HPGDCYP2C9 | |
| SCHEMBL19036473 | 0.71 | YTHDC1 (0.44) | YTHDC1ALDH1A1SMN1; SMN2HPGDCYP2C9 | |
| SCHEMBL20079687 | 0.70 | KMT2A (0.34) | YTHDC1ALDH1A1SMN1; SMN2HPGDCYP2C9 | |
| SCHEMBL21133444 | 0.69 | KMT2A (0.34) | YTHDC1ALDH1A1SMN1; SMN2HPGDCYP2C9 | |
| SCHEMBL11357236 | 0.68 | KMT2A (0.51) | ALDH1A1HPGDCYP2C9CYP2C19GAA | |
| SCHEMBL20161578 | 0.67 | HTT (0.50) | YTHDC1ALDH1A1SMN1; SMN2CYP2C19GAA | |
| SCHEMBL19036600 | 0.67 | YTHDC1 (0.37) | YTHDC1 | |
| SCHEMBL20161984 | 0.66 | MEN1 (0.52) | ALDH1A1SMN1; SMN2GAAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3184527-A1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | Hydra Biosciences, Inc. (US) | 2017-06-28 | — | — | EP | disclosed |