Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 3/20 | 0.40 |
| ▸ | LTA4H | P09960 | 3/20 | 0.39 |
| ▸ | CPA3 | P15088 | 1/20 | 0.39 |
| ▸ | EPOR | P19235 | 1/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6955548 | 0.89 | FOLH1 (0.46) | FOLH1LTA4HCPA3EPORSLC1A3 | |
| SCHEMBL7394633 | 0.78 | FOLH1 (0.37) | FOLH1CPA3EPOR | |
| SCHEMBL7084386 | 0.78 | FOLH1 (0.41) | FOLH1LTA4HCPA3FFAR1FFAR4 | |
| SCHEMBL7420915 | 0.78 | SLC1A1 (0.44) | SLC1A3SLC1A2SLC1A1MEN1CYP1A2 | |
| SCHEMBL6299671 | 0.77 | ALDH1A1 (0.43) | FOLH1LTA4HSLC1A3SLC1A2SLC1A1 | |
| SCHEMBL6298147 | 0.77 | ALDH1A1 (0.43) | FOLH1LTA4HSLC1A3SLC1A2SLC1A1 | |
| SCHEMBL10540689 | 0.76 | MAPT (0.42) | FOLH1LTA4HALOX5 | |
| SCHEMBL10686536 | 0.76 | CYP1A2 (0.43) | FOLH1CPA3SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL16166282 | 0.75 | SLC1A3 (0.41) | SLC1A3SLC1A2SLC1A1MEN1CYP1A2 | |
| SCHEMBL7515528 | 0.75 | SLC1A3 (0.38) | FOLH1LTA4HSLC1A3SLC1A2SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4021450-A1 | METHODS OF TREATING BREAST CANCER WITH TETRAHYDRONAPHTHALENE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | Arvinas Operations, Inc. (US) | 2022-07-06 | — | — | EP | disclosed |
| WO-2021041348-A1 | METHODS OF TREATING BREAST CANCER WITH TETRAHYDRONAPHTHALENE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | ARVINAS OPERATIONS, INC. (US) | 2021-03-04 | — | — | WO | disclosed |
| WO-2011050962-A1 | ACID ADDITION SALTS OF LENALIDOMIDE | RATIOPHARM GMBH (DE) | 2011-05-05 | — | — | WO | disclosed |