Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.45 |
| ▸ | MASP2 | O00187 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SMO | Q99835 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1907783 | 0.89 | PDPK1 (0.38) | NAMPTMASP2MEN1KMT2A | |
| SCHEMBL1904701 | 0.88 | NAMPT (0.45) | NAMPTMASP2EHMT2GAAL3MBTL1 | |
| SCHEMBL1907648 | 0.87 | BACE1 (0.44) | NAMPTMASP2ALDH1A1 | |
| SCHEMBL1905074 | 0.86 | NAMPT (0.43) | NAMPTMASP2MEN1KMT2AEHMT2 | |
| SCHEMBL1432011 | 0.86 | NAMPT (0.45) | NAMPTMASP2MEN1KMT2AEHMT2 | |
| SCHEMBL1431865 | 0.86 | NAMPT (0.45) | NAMPTMASP2MEN1KMT2AEHMT2 | |
| SCHEMBL1902650 | 0.85 | NAMPT (0.42) | NAMPTMASP2LMNACCR2 | |
| SCHEMBL1432449 | 0.85 | NAMPT (0.43) | NAMPTMASP2KMT2AEHMT2GAA | |
| SCHEMBL1432545 | 0.84 | NAMPT (0.44) | NAMPTMASP2MEN1KMT2AEHMT2 | |
| SCHEMBL1901312 | 0.84 | NAMPT (0.45) | NAMPTMASP2MEN1KMT2AEHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | claimed |
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | disclosed |