SCHEMBL190443

SCHEMBL190443

CN(C)c1c(Cl)ccc(-c2cc(N)c(Cl)c(C(=O)O)n2)c1F

nearest known ligand 0.34

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 1/20 0.34
KMO O15229 6/20 0.33
CYP3A4 P08684 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
EIF4E P06730 5/20 0.31
MEN1 O00255 1/20 0.30
CYP2C9 P11712 1/20 0.30
CYP2C19 P33261 1/20 0.30
KMT2A Q03164 1/20 0.30
HSD17B10 Q99714 1/20 0.30
MAP4K1 Q92918 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2469718 0.89 CYP3A4 (0.35) DHODHKMOCYP3A4TDP1MEN1
SCHEMBL3327859 0.89 TDP1 (0.38) DHODHKMOCYP3A4TDP1EIF4E
SCHEMBL121226 0.89 KDM4E (0.38) KMT2AMAP4K1
SCHEMBL29442492 0.89 KDM4E (0.38) KMT2AMAP4K1
SCHEMBL2469848 0.85 PPARA (0.35) KMOCYP3A4TDP1EIF4EMEN1
SCHEMBL27792235 0.85 MAP4K1 (0.32) DHODHMAP4K1
SCHEMBL2467629 0.84 FFAR4 (0.35) DHODH
SCHEMBL17623448 0.84 KMO (0.35) KMOCYP3A4TDP1EIF4E
SCHEMBL16076564 0.84 KMO (0.36) KMOCYP3A4TDP1EIF4E
SCHEMBL115379 0.83 ALDH1A1 (0.40) KMOCYP3A4HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2060566-B1 Poly-substituted aryls DOW AGROSCIENCES LLC (US) 2016-06-08 EP claimed
EP-2744791-B1 FUNGICIDAL SUBSTITUTED 1-{2-[2-HALO-4-(4-HALOGEN-PHENOXY)-PHENYL]-2-ALKOXY-3-METHYL-BUTYL}-1H-[1,2,4]TRIAZOLE COMPOUNDS BASF SE (DE) 2015-10-28 EP claimed
EP-2731438-B1 FUNGICIDAL ALKYL-SUBSTITUTED 2-[2-CHLORO-4-(4-CHLORO-PHENOXY)-PHENYL]-1-[1,2,4]TRIAZOL-1-YL-ETHANOL COMPOUNDS BASF SE (DE) 2015-04-08 EP claimed
CN-102458130-A Method for increasing the vigor and/or crop yield of agricultural plants under substantially absent pathogen pressure BASF SE 2012-05-16 CN claimed
WO-2020226482-A1 SYNERGISTIC COMPOSITIONS FOR CONTROLLING PLANT PATHOGENS WITH CHITINOLYTIC MICROORGANISMS / ORGANIC ACID COMBINATIONS AND METHOD OF USE THEREOF LAI HONG HENG (MY) 2020-11-12 WO disclosed
EP-3068890-A1 ANTIFUNGAL PENICILLIUM STRAINS, FUNGICIDAL EXTROLITES THEREOF, AND THEIR USE BASF SE (DE) 2016-09-21 EP disclosed
EP-2060566-B1 Poly-substituted aryls DOW AGROSCIENCES LLC (US) 2016-06-08 EP disclosed
EP-2939541-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 EP disclosed
EP-2939540-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 EP disclosed
WO-2015067800-A1 ANTIFUNGAL PENICILLIUM STRAINS, FUNGICIDAL EXTROLITES THEREOF, AND THEIR USE BASF SE (DE) 2015-05-14 WO disclosed
US-8962523-B2 Herbicide/safener combination BAYER CROPSCIENCE AG (DE) 2015-02-24 US disclosed
US-20150051074-A1 HERBICIDE/SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2015-02-19 US disclosed
US-7498468-B2 6-(poly-substituted aryl)-4-aminopicolinates and their use as herbicides DOW AGROSCIENCES LLC (US) 2009-03-03 US disclosed
CN-101360713-A 6- (polysubstituted aryl) -4-aminopicolinates and their use as herbicides DOW AGROSCIENCES LLC (US) 2009-02-04 CN disclosed
EP-1973881-A2 6-(POLY-SUBSTITUTED ARYL)-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES Dow Agrosciences LLC (US) 2008-10-01 EP disclosed
US-20080051596-A1 6-(poly-substituted aryl)-4-aminopicolinates and their use as herbicides DOW AGROSCIENCES LLC (US) 2008-02-28 US disclosed
US-20080045734-A1 6-(poly-substituted aryl)-4-aminopicolinates and their use as herbicides DOW AGROSCIENCES LLC (US) 2008-02-21 US disclosed
US-7314849-B2 6-(poly-substituted aryl)-4-aminopicolinates and their use as herbicides DOW AGROSCIENCES LLC (US) 2008-01-01 US disclosed
US-20070179060-A1 6-(Poly-substituted aryl)-4-aminopicolinates and their use as herbicides CORTEVA AGRISCIENCE LLC 2007-08-02 US disclosed
WO-2007082098-A2 6-(POLY-SUBSTITUTED ARYL)-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2007-07-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080045734-A1 6-(poly-substituted aryl)-4-aminopicolinates and their use as herbicides AAAS, DDT, AADAC DHODH 2935/4885KMO 258/4885CYP3A4 589/4885
US-20070179060-A1 6-(Poly-substituted aryl)-4-aminopicolinates and their use as herbicides AAAS, DDT, AADAC DHODH 2935/4885KMO 258/4885CYP3A4 589/4885
US-20080051596-A1 6-(poly-substituted aryl)-4-aminopicolinates and their use as herbicides AAAS, DDT, AADAC DHODH 2935/4885KMO 258/4885CYP3A4 589/4885
US-20150051074-A1 HERBICIDE/SAFENER COMBINATION DDT, CYP2W1, GAP43 DHODH 237/4885KMO 2242/4885CYP3A4 244/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.