Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 7/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19046529 | 0.89 | CFTR (0.55) | CFTRMEN1KMT2AMAPK1MAPT | |
| SCHEMBL19046558 | 0.82 | CFTR (0.51) | CFTRMEN1KMT2AMAPK1TP53 | |
| SCHEMBL24363056 | 0.81 | CFTR (0.72) | CFTRMEN1KMT2AMAPK1TP53 | |
| SCHEMBL19046446 | 0.80 | CFTR (0.62) | CFTRMEN1KMT2AMAPK1TP53 | |
| SCHEMBL19032856 | 0.79 | CFTR (0.62) | CFTRMEN1KMT2AMAPK1MAPT | |
| SCHEMBL19032808 | 0.76 | CFTR (0.75) | CFTRMEN1KMT2AMAPK1MAPT | |
| SCHEMBL19046531 | 0.75 | CFTR (0.62) | CFTRMEN1KMT2AMAPK1HTT | |
| SCHEMBL19046547 | 0.74 | CFTR (0.69) | CFTRMEN1KMT2AMAPK1MAPT | |
| SCHEMBL19046530 | 0.72 | CFTR (0.67) | CFTRMEN1KMT2AMAPK1TP53 | |
| SCHEMBL19032095 | 0.71 | CFTR (1.00) | CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4071140-B1 | CFTR REGULATORS AND METHODS OF USE THEREOF | UNIV CALIFORNIA (US) | 2024-07-03 | — | — | EP | disclosed |
| EP-4071140-A1 | CFTR REGULATORS AND METHODS OF USE THEREOF | The Regents of The University of California (US) | 2022-10-12 | — | — | EP | disclosed |
| US-11084795-B2 | CFTR regulators and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-08-10 | — | — | US | disclosed |
| US-20190031622-A1 | CFTR REGULATORS AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2019-01-31 | — | — | US | disclosed |
| WO-2017112950-A1 | CFTR REGULATORS AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190031622-A1 | CFTR REGULATORS AND METHODS OF USE THEREOF | CFTR, SLC26A4, CLCN2 | CFTR 1/4885MEN1 4526/4885KMT2A 4498/4885 |
| US-11084795-B2 | CFTR regulators and methods of use thereof | CFTR, SLC26A4, CLCN2 | CFTR 1/4885MEN1 4526/4885KMT2A 4498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.